PIK3CA mutations confer resistance to first-line chemotherapy in colorectal cancer

Chemotherapy represents an important treatment option for colorectal cancer (CRC), but only half of the patients benefit from these regimens. We explored the potential predicting value and mechanism of PIK3CA mutation in CRC chemotherapy. CRC specimens from 440 patients were retrospectively collecte...

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Detalles Bibliográficos
Autores principales: Wang, Qiang, Shi, Yan-long, Zhou, Kai, Wang, Li-li, Yan, Ze-xuan, Liu, Yu-lin, Xu, Li-li, Zhao, Shi-wei, Chu, Hui-li, Shi, Ting-ting, Ma, Qing-hua, Bi, Jingwang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030128/
https://www.ncbi.nlm.nih.gov/pubmed/29970892
http://dx.doi.org/10.1038/s41419-018-0776-6

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