A selective high affinity MYC-binding compound inhibits MYC:MAX interaction and MYC-dependent tumor cell proliferation

MYC is a key player in tumor development, but unfortunately no specific MYC-targeting drugs are clinically available. MYC is strictly dependent on heterodimerization with MAX for transcription activation. Aiming at targeting this interaction, we identified MYCMI-6 in a cell-based protein interaction...

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Detalles Bibliográficos
Autores principales: Castell, Alina, Yan, Qinzi, Fawkner, Karin, Hydbring, Per, Zhang, Fan, Verschut, Vasiliki, Franco, Marcela, Zakaria, Siti Mariam, Bazzar, Wesam, Goodwin, Jacob, Zinzalla, Giovanna, Larsson, Lars-Gunnar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030159/
https://www.ncbi.nlm.nih.gov/pubmed/29968736
http://dx.doi.org/10.1038/s41598-018-28107-4

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