Imbalanced LIMK1 and LIMK2 expression leads to human colorectal cancer progression and metastasis via promoting β-catenin nuclear translocation

Epithelial–mesenchymal transition (EMT)-induced metastasis contributes to human colorectal cancer (CRC) progression, especially in advanced CRC. However, the underlying mechanism of β-catenin in this process is elusive. We identified that LIM domain kinase (LIMK)2 was progressively downregulated wit...

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Detalles Bibliográficos
Autores principales: Zhang, Yue, Li, Aimin, Shi, Jiaolong, Fang, Yuxin, Gu, Chuncai, Cai, Jianqun, Lin, Chuang, Zhao, Liang, Liu, Side
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030168/
https://www.ncbi.nlm.nih.gov/pubmed/29970879
http://dx.doi.org/10.1038/s41419-018-0766-8

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