Cargando…
Task-dependent representations of stimulus and choice in mouse parietal cortex
The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030204/ https://www.ncbi.nlm.nih.gov/pubmed/29968709 http://dx.doi.org/10.1038/s41467-018-05012-y |
_version_ | 1783337099026497536 |
---|---|
author | Pho, Gerald N. Goard, Michael J. Woodson, Jonathan Crawford, Benjamin Sur, Mriganka |
author_facet | Pho, Gerald N. Goard, Michael J. Woodson, Jonathan Crawford, Benjamin Sur, Mriganka |
author_sort | Pho, Gerald N. |
collection | PubMed |
description | The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in primary visual cortex (V1) and PPC during engaged behavior and passive viewing. Unlike V1 neurons, which respond robustly to stimuli in both conditions, most PPC neurons respond exclusively during task engagement. To test whether signals in PPC primarily encoded the stimulus or the animal’s impending choice, we image the same neurons before and after re-training mice with a reversed sensorimotor contingency. Unlike V1 neurons, most PPC neurons reflect the animal’s choice of the new target stimulus after re-training. Mouse PPC is therefore strongly task-dependent, reflects choice more than stimulus, and may play a role in the transformation of visual inputs into motor commands. |
format | Online Article Text |
id | pubmed-6030204 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-60302042018-07-05 Task-dependent representations of stimulus and choice in mouse parietal cortex Pho, Gerald N. Goard, Michael J. Woodson, Jonathan Crawford, Benjamin Sur, Mriganka Nat Commun Article The posterior parietal cortex (PPC) has been implicated in perceptual decisions, but whether its role is specific to sensory processing or sensorimotor transformation is not well understood. Here, we trained mice to perform a go/no-go visual discrimination task and imaged the activity of neurons in primary visual cortex (V1) and PPC during engaged behavior and passive viewing. Unlike V1 neurons, which respond robustly to stimuli in both conditions, most PPC neurons respond exclusively during task engagement. To test whether signals in PPC primarily encoded the stimulus or the animal’s impending choice, we image the same neurons before and after re-training mice with a reversed sensorimotor contingency. Unlike V1 neurons, most PPC neurons reflect the animal’s choice of the new target stimulus after re-training. Mouse PPC is therefore strongly task-dependent, reflects choice more than stimulus, and may play a role in the transformation of visual inputs into motor commands. Nature Publishing Group UK 2018-07-03 /pmc/articles/PMC6030204/ /pubmed/29968709 http://dx.doi.org/10.1038/s41467-018-05012-y Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Article Pho, Gerald N. Goard, Michael J. Woodson, Jonathan Crawford, Benjamin Sur, Mriganka Task-dependent representations of stimulus and choice in mouse parietal cortex |
title | Task-dependent representations of stimulus and choice in mouse parietal cortex |
title_full | Task-dependent representations of stimulus and choice in mouse parietal cortex |
title_fullStr | Task-dependent representations of stimulus and choice in mouse parietal cortex |
title_full_unstemmed | Task-dependent representations of stimulus and choice in mouse parietal cortex |
title_short | Task-dependent representations of stimulus and choice in mouse parietal cortex |
title_sort | task-dependent representations of stimulus and choice in mouse parietal cortex |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030204/ https://www.ncbi.nlm.nih.gov/pubmed/29968709 http://dx.doi.org/10.1038/s41467-018-05012-y |
work_keys_str_mv | AT phogeraldn taskdependentrepresentationsofstimulusandchoiceinmouseparietalcortex AT goardmichaelj taskdependentrepresentationsofstimulusandchoiceinmouseparietalcortex AT woodsonjonathan taskdependentrepresentationsofstimulusandchoiceinmouseparietalcortex AT crawfordbenjamin taskdependentrepresentationsofstimulusandchoiceinmouseparietalcortex AT surmriganka taskdependentrepresentationsofstimulusandchoiceinmouseparietalcortex |