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New (β)N-octadecanoyl-5-hydroxytryptamide: antinociceptive effect and possible mechanism of action in mice

The present study examined the potential antinociceptive activity of C18 5-HT ((β)N-octadecanoyl-5-hydroxytryptamide) using chemical and thermal nociception models in mice. Orally administered C18 5-HT (0.1, 1 and 10 mg/kg) produced significant dose-dependent antinociceptive effects in formalin-, ca...

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Detalles Bibliográficos
Autores principales:	Giorno, Thais Biondino Sardella, Moreira, Iris Gonçalvez da Silva, Rezende, Claudia Moraes, Fernandes, Patricia Dias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030208/ https://www.ncbi.nlm.nih.gov/pubmed/29968799 http://dx.doi.org/10.1038/s41598-018-28355-4

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