Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury

Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues and organs and is a potentially effective treatment for radioactive esophageal injury. In this study, to explore the therapeutic effects of DPSCs on acute radiation-induced esophageal...

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Autores principales: Zhang, Chunwei, Zhang, Yichi, Feng, Zhenning, Zhang, Feifei, Liu, Zishuai, Sun, Xiaoli, Ruan, Mengting, Liu, Mingna, Jin, Shizhu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030227/
https://www.ncbi.nlm.nih.gov/pubmed/29970894
http://dx.doi.org/10.1038/s41419-018-0753-0
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author Zhang, Chunwei
Zhang, Yichi
Feng, Zhenning
Zhang, Feifei
Liu, Zishuai
Sun, Xiaoli
Ruan, Mengting
Liu, Mingna
Jin, Shizhu
author_facet Zhang, Chunwei
Zhang, Yichi
Feng, Zhenning
Zhang, Feifei
Liu, Zishuai
Sun, Xiaoli
Ruan, Mengting
Liu, Mingna
Jin, Shizhu
author_sort Zhang, Chunwei
collection PubMed
description Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues and organs and is a potentially effective treatment for radioactive esophageal injury. In this study, to explore the therapeutic effects of DPSCs on acute radiation-induced esophageal injury, DPSCs were cultured and transplanted into rats with acute radioactive esophageal injuries induced by radioactive (125)I seeds in vivo. In the injured esophagus, PKH26-labeled DPSCs co-localized with PCNA, CK14, CD71, and integrin α6, and the expression levels of these four makers of esophageal stem cells were significantly increased. After DPSC transplantation, the injured esophagus exhibited a greater thickness. In addition, the esophageal function and inflammation recovered faster. The results demonstrated that transplanted DPSCs, which trans-differentiated into esophageal stem cells in vivo, could repair the damaged esophageal tissue.
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spelling pubmed-60302272018-07-06 Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury Zhang, Chunwei Zhang, Yichi Feng, Zhenning Zhang, Feifei Liu, Zishuai Sun, Xiaoli Ruan, Mengting Liu, Mingna Jin, Shizhu Cell Death Dis Article Dental pulp stem cell (DPSC) transplantation has been demonstrated to promote the regeneration and repair of tissues and organs and is a potentially effective treatment for radioactive esophageal injury. In this study, to explore the therapeutic effects of DPSCs on acute radiation-induced esophageal injury, DPSCs were cultured and transplanted into rats with acute radioactive esophageal injuries induced by radioactive (125)I seeds in vivo. In the injured esophagus, PKH26-labeled DPSCs co-localized with PCNA, CK14, CD71, and integrin α6, and the expression levels of these four makers of esophageal stem cells were significantly increased. After DPSC transplantation, the injured esophagus exhibited a greater thickness. In addition, the esophageal function and inflammation recovered faster. The results demonstrated that transplanted DPSCs, which trans-differentiated into esophageal stem cells in vivo, could repair the damaged esophageal tissue. Nature Publishing Group UK 2018-07-03 /pmc/articles/PMC6030227/ /pubmed/29970894 http://dx.doi.org/10.1038/s41419-018-0753-0 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Zhang, Chunwei
Zhang, Yichi
Feng, Zhenning
Zhang, Feifei
Liu, Zishuai
Sun, Xiaoli
Ruan, Mengting
Liu, Mingna
Jin, Shizhu
Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title_full Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title_fullStr Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title_full_unstemmed Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title_short Therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
title_sort therapeutic effect of dental pulp stem cell transplantation on a rat model of radioactivity-induced esophageal injury
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030227/
https://www.ncbi.nlm.nih.gov/pubmed/29970894
http://dx.doi.org/10.1038/s41419-018-0753-0
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