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Crystal Structures of Spleen Tyrosine Kinase in Complex with Two Novel 4-Aminopyrido[4,3-d] Pyrimidine Derivative Inhibitors

Spleen tyrosine kinase (SYK) is a cytosolic non-receptor protein tyrosine kinase. Because SYK mediates key receptor signaling pathways involving the B cell receptor and Fc receptors, SYK is an attractive target for autoimmune disease and cancer treatments. To date, representative oral SYK inhibitors...

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Detalles Bibliográficos
Autores principales:	Lee, Sang Jae, Choi, Jang-Sik, Bong, Seoung Min, Hwang, Hae-Jun, Lee, Jaesang, Song, Ho-Juhn, Lee, Jaekyoo, Kim, Jung-Ho, Koh, Jong Sung, Lee, Byung Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Korean Society for Molecular and Cellular Biology 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030240/ https://www.ncbi.nlm.nih.gov/pubmed/29890824 http://dx.doi.org/10.14348/molcells.2018.2219

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