The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro

A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress...

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Detalles Bibliográficos
Autores principales: Zhao, Chang K., Li, Chan, Wang, Xian H., Bao, Yu J., Yang, Fu H., Huang, Mei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society Publishing 2018
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030274/
https://www.ncbi.nlm.nih.gov/pubmed/30110459
http://dx.doi.org/10.1098/rsos.172317
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author Zhao, Chang K.
Li, Chan
Wang, Xian H.
Bao, Yu J.
Yang, Fu H.
Huang, Mei
author_facet Zhao, Chang K.
Li, Chan
Wang, Xian H.
Bao, Yu J.
Yang, Fu H.
Huang, Mei
author_sort Zhao, Chang K.
collection PubMed
description A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro. These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment.
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spelling pubmed-60302742018-07-17 The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro Zhao, Chang K. Li, Chan Wang, Xian H. Bao, Yu J. Yang, Fu H. Huang, Mei R Soc Open Sci Chemistry A series of conjugates of 10-hydroxy camptothecin (HCPT) with functionalized norcantharidin derivatives were regio-selectively synthesized in the condition of (3-dimethylaminopropyl) ethyl-carbodiimide monohydrochloride in a moderate yield. The synthesized conjugate HCPT pro-drugs can also suppress cancer cell growth in vitro. These conjugated pro-drug constructs possess therapeutic potential as novel bi-functional conjugate platforms for cancer treatment. The Royal Society Publishing 2018-06-13 /pmc/articles/PMC6030274/ /pubmed/30110459 http://dx.doi.org/10.1098/rsos.172317 Text en © 2018 The Authors. http://creativecommons.org/licenses/by/4.0/ Published by the Royal Society under the terms of the Creative Commons Attribution License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original author and source are credited.
spellingShingle Chemistry
Zhao, Chang K.
Li, Chan
Wang, Xian H.
Bao, Yu J.
Yang, Fu H.
Huang, Mei
The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_full The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_fullStr The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_full_unstemmed The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_short The regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
title_sort regio-selective synthesis of 10-hydroxy camptothecin norcantharidin conjugates and their biological activity evaluation in vitro
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030274/
https://www.ncbi.nlm.nih.gov/pubmed/30110459
http://dx.doi.org/10.1098/rsos.172317
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