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Synthesis and molecular docking studies of some novel Schiff bases incorporating 6-butylquinolinedione moiety as potential topoisomerase IIβ inhibitors

A series of novel pyranoquinolinone-based Schiff's bases were designed and synthesized. They were evaluated for topoisomerase IIβ (TOP2B) inhibitory activity, and cytotoxicity against breast cancer cell line (MCF-7) for the development of novel anticancer agents. A molecular docking study was e...

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Detalles Bibliográficos
Autores principales:	Hassanin, Hany M., Serya, Rabah A. T., Abd Elmoneam, Wafaa R., Mostafa, Mai A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Royal Society Publishing 2018
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030276/ https://www.ncbi.nlm.nih.gov/pubmed/30110445 http://dx.doi.org/10.1098/rsos.172407

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