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Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study

The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18–30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years;...

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Autores principales: Domínguez-Sanchéz, María A., Bustos-Cruz, Rosa H., Velasco-Orjuela, Gina P., Quintero, Andrea P., Tordecilla-Sanders, Alejandra, Correa-Bautista, Jorge E., Triana-Reina, Héctor R., García-Hermoso, Antonio, González-Ruíz, Katherine, Peña-Guzmán, Carlos A., Hernández, Enrique, Peña-Ibagon, Jhonatan C., Téllez-T, Luis A., Izquierdo, Mikel, Ramírez-Vélez, Robinson
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030369/
https://www.ncbi.nlm.nih.gov/pubmed/29997519
http://dx.doi.org/10.3389/fphys.2018.00741
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author Domínguez-Sanchéz, María A.
Bustos-Cruz, Rosa H.
Velasco-Orjuela, Gina P.
Quintero, Andrea P.
Tordecilla-Sanders, Alejandra
Correa-Bautista, Jorge E.
Triana-Reina, Héctor R.
García-Hermoso, Antonio
González-Ruíz, Katherine
Peña-Guzmán, Carlos A.
Hernández, Enrique
Peña-Ibagon, Jhonatan C.
Téllez-T, Luis A.
Izquierdo, Mikel
Ramírez-Vélez, Robinson
author_facet Domínguez-Sanchéz, María A.
Bustos-Cruz, Rosa H.
Velasco-Orjuela, Gina P.
Quintero, Andrea P.
Tordecilla-Sanders, Alejandra
Correa-Bautista, Jorge E.
Triana-Reina, Héctor R.
García-Hermoso, Antonio
González-Ruíz, Katherine
Peña-Guzmán, Carlos A.
Hernández, Enrique
Peña-Ibagon, Jhonatan C.
Téllez-T, Luis A.
Izquierdo, Mikel
Ramírez-Vélez, Robinson
author_sort Domínguez-Sanchéz, María A.
collection PubMed
description The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18–30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m(2)) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of <600 MET min/week for >6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m(2) were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85–95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75–85% HRmax) (n = 14), resistance training (12–15 repetitions per set, at 50–70% of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5–76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3–2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6–41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3–53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R(2) = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols. Trial Registration: ClinicalTrials.gov, NCT02915913 (Date: September 22, 2016).
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spelling pubmed-60303692018-07-11 Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study Domínguez-Sanchéz, María A. Bustos-Cruz, Rosa H. Velasco-Orjuela, Gina P. Quintero, Andrea P. Tordecilla-Sanders, Alejandra Correa-Bautista, Jorge E. Triana-Reina, Héctor R. García-Hermoso, Antonio González-Ruíz, Katherine Peña-Guzmán, Carlos A. Hernández, Enrique Peña-Ibagon, Jhonatan C. Téllez-T, Luis A. Izquierdo, Mikel Ramírez-Vélez, Robinson Front Physiol Physiology The purpose of this study was to compare the neurotrophic factor response following one session of high-intensity exercise, resistance training or both in a cohort of physically inactive overweight adults aged 18–30 years old. A randomized, parallel-group clinical trial of 51 men (23.6 ± 3.5 years; 83.5 ± 7.8 kg; 28.0 ± 1.9 kg/m(2)) who are physically inactive (i.e., < 150 min of moderate-intensity exercise per week or IPAQ score of <600 MET min/week for >6 months) and are either abdominally obese (waist circumference ≥90 cm) or have a body mass index, BMI ≥25 and ≤ 30 kg/m(2) were randomized to the following four exercise protocols: high-intensity exercise (4 × 4 min intervals at 85–95% maximum heart rate [HRmax] interspersed with 4 min of recovery at 75–85% HRmax) (n = 14), resistance training (12–15 repetitions per set, at 50–70% of one repetition maximum with 60 s of recovery) (n = 12), combined high-intensity and resistance exercise (n = 13), or non-exercising control (n = 12). The plasma levels of neurotrophin-3 (NT-3), neurotrophin-4 (also known as neurotrophin 4/5; NT-4 or NT-4/5), and brain-derived neurotrophic factor (BDNF) were determined before (pre-exercise) and 1-min post-exercise for each protocol session. Resistance training induced significant increases in NT-3 (+39.6 ng/mL [95% CI, 2.5–76.6; p = 0.004], and NT-4/5 (+1.3 ng/mL [95% CI, 0.3–2.3; p = 0.014]), respectively. Additionally, combined training results in favorable effects on BDNF (+22.0, 95% CI, 2.6–41.5; p = 0.029) and NT-3 (+32.9 ng/mL [95% CI, 12.3–53.4; p = 0.004]), respectively. The regression analysis revealed a significant positive relationship between changes in BDNF levels and changes in NT-4/5 levels from baseline to immediate post-exercise in the combined training group (R(2) = 0.345, p = 0.034) but not the other intervention groups. The findings indicate that acute resistance training and combined exercise increase neurotrophic factors in physically inactive overweight adults. Further studies are required to determine the biological importance of changes in neurotrophic responses in overweight men and chronic effects of these exercise protocols. Trial Registration: ClinicalTrials.gov, NCT02915913 (Date: September 22, 2016). Frontiers Media S.A. 2018-06-27 /pmc/articles/PMC6030369/ /pubmed/29997519 http://dx.doi.org/10.3389/fphys.2018.00741 Text en Copyright © 2018 Domínguez-Sanchéz, Bustos-Cruz, Velasco-Orjuela, Quintero, Tordecilla-Sanders, Correa-Bautista, Triana-Reina, García-Hermoso, González-Ruíz, Peña-Guzmán, Hernández, Peña-Ibagon, Téllez-T, Izquierdo and Ramírez-Vélez. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Domínguez-Sanchéz, María A.
Bustos-Cruz, Rosa H.
Velasco-Orjuela, Gina P.
Quintero, Andrea P.
Tordecilla-Sanders, Alejandra
Correa-Bautista, Jorge E.
Triana-Reina, Héctor R.
García-Hermoso, Antonio
González-Ruíz, Katherine
Peña-Guzmán, Carlos A.
Hernández, Enrique
Peña-Ibagon, Jhonatan C.
Téllez-T, Luis A.
Izquierdo, Mikel
Ramírez-Vélez, Robinson
Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title_full Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title_fullStr Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title_full_unstemmed Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title_short Acute Effects of High Intensity, Resistance, or Combined Protocol on the Increase of Level of Neurotrophic Factors in Physically Inactive Overweight Adults: The BrainFit Study
title_sort acute effects of high intensity, resistance, or combined protocol on the increase of level of neurotrophic factors in physically inactive overweight adults: the brainfit study
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030369/
https://www.ncbi.nlm.nih.gov/pubmed/29997519
http://dx.doi.org/10.3389/fphys.2018.00741
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