Cargando…

Pneumococcal Conjugate Vaccine impact assessment in Bangladesh

The study examines the impact of the introduction of 10-valent Pneumococcal Conjugate Vaccine (PCV10) into Bangladesh’s national vaccine program. PCV10 is administered to children under 1 year-old; the scheduled ages of administration are at 6, 10, and 18 weeks. The study is conducted in ~770,000 po...

Descripción completa

Detalles Bibliográficos
Autores principales: Baqui, Abdullah H., McCollum, Eric D., Saha, Samir K., Roy, Arun K., Chowdhury, Nabidul H., Harrison, Meagan, Hanif, Abu Abdullah Mohammad, Simmons, Nicole, Mahmud, Arif, Begum, Nazma, Ahmed, Salahuddin, Khan, Ahad M., Ahmed, Zabed Bin, Islam, Maksuda, Mitra, Dipak, Quaiyum, Abdul, Chavez, Miguel A., Pervaiz, Farhan, Miele, Catherine H., Schuh, Holly B., Khanam, Rasheda, Checkley, William, Moulton, Lawrence H., Santosham, Mathuram
Formato: Online Artículo Texto
Lenguaje:English
Publicado: F1000 Research Limited 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030398/
https://www.ncbi.nlm.nih.gov/pubmed/29984359
http://dx.doi.org/10.12688/gatesopenres.12805.1
_version_ 1783337144252628992
author Baqui, Abdullah H.
McCollum, Eric D.
Saha, Samir K.
Roy, Arun K.
Chowdhury, Nabidul H.
Harrison, Meagan
Hanif, Abu Abdullah Mohammad
Simmons, Nicole
Mahmud, Arif
Begum, Nazma
Ahmed, Salahuddin
Khan, Ahad M.
Ahmed, Zabed Bin
Islam, Maksuda
Mitra, Dipak
Quaiyum, Abdul
Chavez, Miguel A.
Pervaiz, Farhan
Miele, Catherine H.
Schuh, Holly B.
Khanam, Rasheda
Checkley, William
Moulton, Lawrence H.
Santosham, Mathuram
author_facet Baqui, Abdullah H.
McCollum, Eric D.
Saha, Samir K.
Roy, Arun K.
Chowdhury, Nabidul H.
Harrison, Meagan
Hanif, Abu Abdullah Mohammad
Simmons, Nicole
Mahmud, Arif
Begum, Nazma
Ahmed, Salahuddin
Khan, Ahad M.
Ahmed, Zabed Bin
Islam, Maksuda
Mitra, Dipak
Quaiyum, Abdul
Chavez, Miguel A.
Pervaiz, Farhan
Miele, Catherine H.
Schuh, Holly B.
Khanam, Rasheda
Checkley, William
Moulton, Lawrence H.
Santosham, Mathuram
author_sort Baqui, Abdullah H.
collection PubMed
description The study examines the impact of the introduction of 10-valent Pneumococcal Conjugate Vaccine (PCV10) into Bangladesh’s national vaccine program. PCV10 is administered to children under 1 year-old; the scheduled ages of administration are at 6, 10, and 18 weeks. The study is conducted in ~770,000 population containing ~90,000 <5 children in Sylhet, Bangladesh and has five objectives: 1) To collect data on community-based pre-PCV incidence rates of invasive pneumococcal diseases (IPD) in 0-59 month-old children in Sylhet, Bangladesh; 2) To evaluate the effectiveness of PCV10 introduction on Vaccine Type (VT) IPD in 3-59 month-old children using an incident case-control study design. Secondary aims include measuring the effects of PCV10 introduction on all IPD in 3-59 month-old children using case-control study design, and quantifying the emergence of Non Vaccine Type IPD; 3) To evaluate the effectiveness of PCV10 introduction on chest radiograph-confirmed pneumonia in children 3-35 months old using incident case-control study design. We will estimate the incidence trend of clinical and radiologically-confirmed pneumonia in 3-35 month-old children in the study area before and after introduction of PCV10; 4) To determine the feasibility and utility of lung ultrasound for the diagnosis of pediatric pneumonia in a large sample of children in a resource-limited setting. We will also evaluate the effectiveness of PCV10 introduction on ultrasound-confirmed pneumonia in 3-35 month-old children using an incident case-control design and to examine the incidence trend of ultrasound-confirmed pneumonia in 3-35 month-old children in the study area before and after PCV10 introduction; and 5) To determine the direct and indirect effects of vaccination status on nasopharyngeal colonization on VT pneumococci among children with pneumonia .  This paper presents the methodology. The study will allow us to conduct a comprehensive and robust assessment of the impact of national introduction of PCV10 on pneumococcal disease in Bangladesh.
format Online
Article
Text
id pubmed-6030398
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher F1000 Research Limited
record_format MEDLINE/PubMed
spelling pubmed-60303982018-07-05 Pneumococcal Conjugate Vaccine impact assessment in Bangladesh Baqui, Abdullah H. McCollum, Eric D. Saha, Samir K. Roy, Arun K. Chowdhury, Nabidul H. Harrison, Meagan Hanif, Abu Abdullah Mohammad Simmons, Nicole Mahmud, Arif Begum, Nazma Ahmed, Salahuddin Khan, Ahad M. Ahmed, Zabed Bin Islam, Maksuda Mitra, Dipak Quaiyum, Abdul Chavez, Miguel A. Pervaiz, Farhan Miele, Catherine H. Schuh, Holly B. Khanam, Rasheda Checkley, William Moulton, Lawrence H. Santosham, Mathuram Gates Open Res Study Protocol The study examines the impact of the introduction of 10-valent Pneumococcal Conjugate Vaccine (PCV10) into Bangladesh’s national vaccine program. PCV10 is administered to children under 1 year-old; the scheduled ages of administration are at 6, 10, and 18 weeks. The study is conducted in ~770,000 population containing ~90,000 <5 children in Sylhet, Bangladesh and has five objectives: 1) To collect data on community-based pre-PCV incidence rates of invasive pneumococcal diseases (IPD) in 0-59 month-old children in Sylhet, Bangladesh; 2) To evaluate the effectiveness of PCV10 introduction on Vaccine Type (VT) IPD in 3-59 month-old children using an incident case-control study design. Secondary aims include measuring the effects of PCV10 introduction on all IPD in 3-59 month-old children using case-control study design, and quantifying the emergence of Non Vaccine Type IPD; 3) To evaluate the effectiveness of PCV10 introduction on chest radiograph-confirmed pneumonia in children 3-35 months old using incident case-control study design. We will estimate the incidence trend of clinical and radiologically-confirmed pneumonia in 3-35 month-old children in the study area before and after introduction of PCV10; 4) To determine the feasibility and utility of lung ultrasound for the diagnosis of pediatric pneumonia in a large sample of children in a resource-limited setting. We will also evaluate the effectiveness of PCV10 introduction on ultrasound-confirmed pneumonia in 3-35 month-old children using an incident case-control design and to examine the incidence trend of ultrasound-confirmed pneumonia in 3-35 month-old children in the study area before and after PCV10 introduction; and 5) To determine the direct and indirect effects of vaccination status on nasopharyngeal colonization on VT pneumococci among children with pneumonia .  This paper presents the methodology. The study will allow us to conduct a comprehensive and robust assessment of the impact of national introduction of PCV10 on pneumococcal disease in Bangladesh. F1000 Research Limited 2018-04-26 /pmc/articles/PMC6030398/ /pubmed/29984359 http://dx.doi.org/10.12688/gatesopenres.12805.1 Text en Copyright: © 2018 Baqui AH et al. http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution Licence, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Study Protocol
Baqui, Abdullah H.
McCollum, Eric D.
Saha, Samir K.
Roy, Arun K.
Chowdhury, Nabidul H.
Harrison, Meagan
Hanif, Abu Abdullah Mohammad
Simmons, Nicole
Mahmud, Arif
Begum, Nazma
Ahmed, Salahuddin
Khan, Ahad M.
Ahmed, Zabed Bin
Islam, Maksuda
Mitra, Dipak
Quaiyum, Abdul
Chavez, Miguel A.
Pervaiz, Farhan
Miele, Catherine H.
Schuh, Holly B.
Khanam, Rasheda
Checkley, William
Moulton, Lawrence H.
Santosham, Mathuram
Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title_full Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title_fullStr Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title_full_unstemmed Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title_short Pneumococcal Conjugate Vaccine impact assessment in Bangladesh
title_sort pneumococcal conjugate vaccine impact assessment in bangladesh
topic Study Protocol
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030398/
https://www.ncbi.nlm.nih.gov/pubmed/29984359
http://dx.doi.org/10.12688/gatesopenres.12805.1
work_keys_str_mv AT baquiabdullahh pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT mccollumericd pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT sahasamirk pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT royarunk pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT chowdhurynabidulh pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT harrisonmeagan pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT hanifabuabdullahmohammad pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT simmonsnicole pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT mahmudarif pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT begumnazma pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT ahmedsalahuddin pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT khanahadm pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT ahmedzabedbin pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT islammaksuda pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT mitradipak pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT quaiyumabdul pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT chavezmiguela pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT pervaizfarhan pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT mielecatherineh pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT schuhhollyb pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT khanamrasheda pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT checkleywilliam pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT moultonlawrenceh pneumococcalconjugatevaccineimpactassessmentinbangladesh
AT santoshammathuram pneumococcalconjugatevaccineimpactassessmentinbangladesh