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The Temporal Dynamics of Arc Expression Regulate Cognitive Flexibility

Neuronal activity regulates the transcription and translation of the immediate-early gene Arc/Arg3.1, a key mediator of synaptic plasticity. Proteasome-dependent degradation of Arc tightly limits its temporal expression, yet the significance of this regulation remains unknown. We disrupted the tempo...

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Detalles Bibliográficos
Autores principales:	Wall, Mark J., Collins, Dawn R., Chery, Samantha L., Allen, Zachary D., Pastuzyn, Elissa D., George, Arlene J., Nikolova, Viktoriya D., Moy, Sheryl S., Philpot, Benjamin D., Shepherd, Jason D., Müller, Jürgen, Ehlers, Michael D., Mabb, Angela M., Corrêa, Sonia A.L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030446/ https://www.ncbi.nlm.nih.gov/pubmed/29861284 http://dx.doi.org/10.1016/j.neuron.2018.05.012

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