Cargando…
BROADLY NEUTRALIZING ANTIBODIES FROM HUMAN SURVIVORS TARGET A CONSERVED SITE IN THE EBOLA VIRUS GLYCOPROTEIN HR2/MPER REGION
Ebola virus (EBOV) in humans causes a severe illness with high mortality rates. Several strategies have been developed in the past to treat EBOV infection, including the antibody cocktail ZMapp(TM) that has been shown to be effective in nonhuman primate models of infection(1) and has been used under...
Autores principales: | Flyak, Andrew I., Kuzmina, Natalia, Murin, Charles D., Bryan, Christopher, Davidson, Edgar, Gilchuk, Pavlo, Gulka, Christopher P., Ilinykh, Philipp A., Shen, Xiaoli, Huang, Kai, Ramanathan, Palaniappan, Turner, Hannah, Fusco, Marnie L., Lampley, Rebecca, Kose, Nurgun, King, Hannah, Sapparapu, Gopal, Doranz, Benjamin J., Ksiazek, Thomas G., Wright, David W., Saphire, Erica Ollmann, Ward, Andrew B., Bukreyev, Alexander, Crowe, James E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030461/ https://www.ncbi.nlm.nih.gov/pubmed/29736037 http://dx.doi.org/10.1038/s41564-018-0157-z |
Ejemplares similares
-
Epitope-focused immunogen design based on the ebolavirus glycoprotein HR2-MPER region
por: Schoeder, Clara T., et al.
Publicado: (2022) -
Cross-reactive neutralizing human survivor monoclonal antibody BDBV223 targets the ebolavirus stalk
por: King, Liam B., et al.
Publicado: (2019) -
Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies
por: Murin, Charles D., et al.
Publicado: (2021) -
Multifunctional Pan-ebolavirus Antibody Recognizes a Site of Broad Vulnerability on the Ebolavirus Glycoprotein
por: Gilchuk, Pavlo, et al.
Publicado: (2018) -
Antiviral protection by antibodies targeting the glycan cap of Ebola virus glycoprotein requires activation of the complement system
por: Bukreyev, Alexander, et al.
Publicado: (2023)