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Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques
Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIV(SF1...
Autores principales: | , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030487/ https://www.ncbi.nlm.nih.gov/pubmed/29855550 http://dx.doi.org/10.1038/s41385-018-0025-4 |
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author | Liu, JB Li, JL Zhuang, K Liu, H Wang, X Xiao, QH Li, XD Zhou, RH Zhou, L Ma, TC Zhou, W Liu, MQ Ho, WZ |
author_facet | Liu, JB Li, JL Zhuang, K Liu, H Wang, X Xiao, QH Li, XD Zhou, RH Zhou, L Ma, TC Zhou, W Liu, MQ Ho, WZ |
author_sort | Liu, JB |
collection | PubMed |
description | Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIV(SF162P3N). This protection has a per-exposure risk reduction of 91.5% (P=0.0009; log-rank test) and a complete protection of 87.5% (P<0.001; Fisher's exact test). All protected animals showed no evidence of systemic and mucosal SHIV infection as demonstrated by the absence of viral RNA, DNA and antibodies. In contrast, all controls became infected after repeated SHIV challenges (a median of 2.5 times, range of 1-8 times). Mechanistically, EGCG could block the binding of HIV-1 gp120 to CD4 receptor and suppress the macrophage infiltration/activation in the rectal mucosa of macaques. These data support further clinical evaluation and development of EGCG as a novel, safe and cost-effective microbicide for preventing sexual transmission of HIV-1. |
format | Online Article Text |
id | pubmed-6030487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
record_format | MEDLINE/PubMed |
spelling | pubmed-60304872018-11-30 Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques Liu, JB Li, JL Zhuang, K Liu, H Wang, X Xiao, QH Li, XD Zhou, RH Zhou, L Ma, TC Zhou, W Liu, MQ Ho, WZ Mucosal Immunol Article Epigallocatechin-3-gallate (EGCG), a natural and major ingredient of green tea, has been shown to have anti-inflammation and anti-HIV-1 properties. We demonstrated that the intrarectal administration of EGCG could protect rhesus macaques from repetitive, intrarectal challenges with low-dose SHIV(SF162P3N). This protection has a per-exposure risk reduction of 91.5% (P=0.0009; log-rank test) and a complete protection of 87.5% (P<0.001; Fisher's exact test). All protected animals showed no evidence of systemic and mucosal SHIV infection as demonstrated by the absence of viral RNA, DNA and antibodies. In contrast, all controls became infected after repeated SHIV challenges (a median of 2.5 times, range of 1-8 times). Mechanistically, EGCG could block the binding of HIV-1 gp120 to CD4 receptor and suppress the macrophage infiltration/activation in the rectal mucosa of macaques. These data support further clinical evaluation and development of EGCG as a novel, safe and cost-effective microbicide for preventing sexual transmission of HIV-1. 2018-05-31 2018-07 /pmc/articles/PMC6030487/ /pubmed/29855550 http://dx.doi.org/10.1038/s41385-018-0025-4 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms |
spellingShingle | Article Liu, JB Li, JL Zhuang, K Liu, H Wang, X Xiao, QH Li, XD Zhou, RH Zhou, L Ma, TC Zhou, W Liu, MQ Ho, WZ Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title | Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title_full | Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title_fullStr | Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title_full_unstemmed | Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title_short | Epigallocatechin-3-gallate local pre-exposure application prevents SHIV rectal infection of macaques |
title_sort | epigallocatechin-3-gallate local pre-exposure application prevents shiv rectal infection of macaques |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030487/ https://www.ncbi.nlm.nih.gov/pubmed/29855550 http://dx.doi.org/10.1038/s41385-018-0025-4 |
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