Cargando…

Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes

Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold coating and thermal sensitivity of liposome compositions, to a...

Descripción completa

Detalles Bibliográficos
Autores principales: Knights-Mitchell, Shellie S., Romanowski, Marek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030767/
https://www.ncbi.nlm.nih.gov/pubmed/29977741
http://dx.doi.org/10.7150/ntno.22544
_version_ 1783337189443108864
author Knights-Mitchell, Shellie S.
Romanowski, Marek
author_facet Knights-Mitchell, Shellie S.
Romanowski, Marek
author_sort Knights-Mitchell, Shellie S.
collection PubMed
description Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold coating and thermal sensitivity of liposome compositions, to achieve a drug delivery system that rapidly releases doxorubicin in response to external stimulus. Methods: Thermosensitive liposomes were loaded with doxorubicin and gold-coated to produce plasmon resonant drug delivery system. Plasmon resonance facilitates release of contents upon near-infrared laser illumination, thus providing spatial and temporal control of the process. This controlled delivery system was compared to thermosensitive liposomes without gold coating and to the FDA-approved Doxil that was gold-coated to create a plasmon resonant coating. Release of doxorubicin from the gold-coated thermosensitive liposomes was further confirmed by tests of cell viability. Results: Upon laser illumination at 760 nm and 88 mW/cm(2) power density, permeability of plasmon resonant liposomes increased by three orders of magnitude, from 70×10(-12) to 60,000x10(-12) cm/s. In control experiments, mild hyperthermia (42°C) increased permeability of these thermosensitive liposomes to just 3,700×10(-12) cm/s. Neither hyperthermia nor laser illumination elicit content release from Doxil or plasmon resonant Doxil obtained by gold coating. Laser-induced release of doxorubicin from plasmon resonant thermosensitive liposomes resulted in the loss of cell viability significantly greater than in any of the control groups. Conclusion: Combination of thermosensitive liposomes with plasmon resonant coating enables rapid, controlled release, not currently available in pharmaceutical formulations of anticancer drugs.
format Online
Article
Text
id pubmed-6030767
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher Ivyspring International Publisher
record_format MEDLINE/PubMed
spelling pubmed-60307672018-07-05 Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes Knights-Mitchell, Shellie S. Romanowski, Marek Nanotheranostics Research Paper Precise control of drug release from nanoparticles can improve efficacy and reduce systemic toxicity associated with administration of certain medications. Here, we combined two phenomena, photothermal conversion in plasmon resonant gold coating and thermal sensitivity of liposome compositions, to achieve a drug delivery system that rapidly releases doxorubicin in response to external stimulus. Methods: Thermosensitive liposomes were loaded with doxorubicin and gold-coated to produce plasmon resonant drug delivery system. Plasmon resonance facilitates release of contents upon near-infrared laser illumination, thus providing spatial and temporal control of the process. This controlled delivery system was compared to thermosensitive liposomes without gold coating and to the FDA-approved Doxil that was gold-coated to create a plasmon resonant coating. Release of doxorubicin from the gold-coated thermosensitive liposomes was further confirmed by tests of cell viability. Results: Upon laser illumination at 760 nm and 88 mW/cm(2) power density, permeability of plasmon resonant liposomes increased by three orders of magnitude, from 70×10(-12) to 60,000x10(-12) cm/s. In control experiments, mild hyperthermia (42°C) increased permeability of these thermosensitive liposomes to just 3,700×10(-12) cm/s. Neither hyperthermia nor laser illumination elicit content release from Doxil or plasmon resonant Doxil obtained by gold coating. Laser-induced release of doxorubicin from plasmon resonant thermosensitive liposomes resulted in the loss of cell viability significantly greater than in any of the control groups. Conclusion: Combination of thermosensitive liposomes with plasmon resonant coating enables rapid, controlled release, not currently available in pharmaceutical formulations of anticancer drugs. Ivyspring International Publisher 2018-06-21 /pmc/articles/PMC6030767/ /pubmed/29977741 http://dx.doi.org/10.7150/ntno.22544 Text en © Ivyspring International Publisher This is an open access article distributed under the terms of the Creative Commons Attribution (CC BY-NC) license (https://creativecommons.org/licenses/by-nc/4.0/). See http://ivyspring.com/terms for full terms and conditions.
spellingShingle Research Paper
Knights-Mitchell, Shellie S.
Romanowski, Marek
Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title_full Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title_fullStr Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title_full_unstemmed Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title_short Near-Infrared Activated Release of Doxorubicin from Plasmon Resonant Liposomes
title_sort near-infrared activated release of doxorubicin from plasmon resonant liposomes
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030767/
https://www.ncbi.nlm.nih.gov/pubmed/29977741
http://dx.doi.org/10.7150/ntno.22544
work_keys_str_mv AT knightsmitchellshellies nearinfraredactivatedreleaseofdoxorubicinfromplasmonresonantliposomes
AT romanowskimarek nearinfraredactivatedreleaseofdoxorubicinfromplasmonresonantliposomes