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Medication adherence to antiretroviral therapy among newly treated people living with HIV

BACKGROUND: Free antiretroviral therapy has been implemented in China since 2004, but adherence to antiretroviral therapy among people living with HIV is suboptimal. The effectiveness of antiretroviral therapy is subject to medication adherence, which decreases with prolonged treatment times. The ai...

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Autores principales: Yu, Yang, Luo, Dan, Chen, Xi, Huang, Zhulin, Wang, Min, Xiao, Shuiyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030792/
https://www.ncbi.nlm.nih.gov/pubmed/29973167
http://dx.doi.org/10.1186/s12889-018-5731-z
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author Yu, Yang
Luo, Dan
Chen, Xi
Huang, Zhulin
Wang, Min
Xiao, Shuiyuan
author_facet Yu, Yang
Luo, Dan
Chen, Xi
Huang, Zhulin
Wang, Min
Xiao, Shuiyuan
author_sort Yu, Yang
collection PubMed
description BACKGROUND: Free antiretroviral therapy has been implemented in China since 2004, but adherence to antiretroviral therapy among people living with HIV is suboptimal. The effectiveness of antiretroviral therapy is subject to medication adherence, which decreases with prolonged treatment times. The aim of this study was to investigate medication adherence and related factors among people living with HIV with newly initiated antiretroviral therapy. METHODS: This observational study was conducted in consecutive samples of people living with HIV who had newly initiated antiretroviral therapy. Participants were recruited between March 1, 2013, and August 31, 2014, from the local Center for Disease Control and Prevention and Infectious Disease hospital in a capital city in central China. A standard set of questionnaires was adopted, including the Community Programs for Clinical Research on AIDS Antiretroviral Medications and Self-Report Questionnaire (CPCRA), the Patient Health Questionnaire-9 (PHQ-9) and the 7-item Generalized Anxiety Disorder Scale (GAD-7). T-test, Chi square test and multivariate logistic regression analysis with backward stepwise were performed to explore factors that might influence medication adherence. RESULTS: Of the 207 participants, 85.5% of the participants (177/207) were categorized with good adherence, and 14.5% (30/207) with poor adherence. The multivariate logistic regression analyses showed that participants with positive depression (OR = 5.95, 95% CI: 2.34–15.11) and without disclosure of their HIV status to others (OR = 2.62, 95% CI: 1.06–6.50) were more susceptible to poor adherence. CONCLUSIONS: One-sixth of the participants reported suboptimal medication adherence within the first 6 months. Factors associated with poor adherence included non-disclosure of their HIV status, had positive depression. Tailored interventions, such as effective psychological coping strategies, should be implemented for people living with HIV with newly initiated antiretroviral therapy to improve their medication adherence.
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spelling pubmed-60307922018-07-09 Medication adherence to antiretroviral therapy among newly treated people living with HIV Yu, Yang Luo, Dan Chen, Xi Huang, Zhulin Wang, Min Xiao, Shuiyuan BMC Public Health Research Article BACKGROUND: Free antiretroviral therapy has been implemented in China since 2004, but adherence to antiretroviral therapy among people living with HIV is suboptimal. The effectiveness of antiretroviral therapy is subject to medication adherence, which decreases with prolonged treatment times. The aim of this study was to investigate medication adherence and related factors among people living with HIV with newly initiated antiretroviral therapy. METHODS: This observational study was conducted in consecutive samples of people living with HIV who had newly initiated antiretroviral therapy. Participants were recruited between March 1, 2013, and August 31, 2014, from the local Center for Disease Control and Prevention and Infectious Disease hospital in a capital city in central China. A standard set of questionnaires was adopted, including the Community Programs for Clinical Research on AIDS Antiretroviral Medications and Self-Report Questionnaire (CPCRA), the Patient Health Questionnaire-9 (PHQ-9) and the 7-item Generalized Anxiety Disorder Scale (GAD-7). T-test, Chi square test and multivariate logistic regression analysis with backward stepwise were performed to explore factors that might influence medication adherence. RESULTS: Of the 207 participants, 85.5% of the participants (177/207) were categorized with good adherence, and 14.5% (30/207) with poor adherence. The multivariate logistic regression analyses showed that participants with positive depression (OR = 5.95, 95% CI: 2.34–15.11) and without disclosure of their HIV status to others (OR = 2.62, 95% CI: 1.06–6.50) were more susceptible to poor adherence. CONCLUSIONS: One-sixth of the participants reported suboptimal medication adherence within the first 6 months. Factors associated with poor adherence included non-disclosure of their HIV status, had positive depression. Tailored interventions, such as effective psychological coping strategies, should be implemented for people living with HIV with newly initiated antiretroviral therapy to improve their medication adherence. BioMed Central 2018-07-04 /pmc/articles/PMC6030792/ /pubmed/29973167 http://dx.doi.org/10.1186/s12889-018-5731-z Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Research Article
Yu, Yang
Luo, Dan
Chen, Xi
Huang, Zhulin
Wang, Min
Xiao, Shuiyuan
Medication adherence to antiretroviral therapy among newly treated people living with HIV
title Medication adherence to antiretroviral therapy among newly treated people living with HIV
title_full Medication adherence to antiretroviral therapy among newly treated people living with HIV
title_fullStr Medication adherence to antiretroviral therapy among newly treated people living with HIV
title_full_unstemmed Medication adherence to antiretroviral therapy among newly treated people living with HIV
title_short Medication adherence to antiretroviral therapy among newly treated people living with HIV
title_sort medication adherence to antiretroviral therapy among newly treated people living with hiv
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030792/
https://www.ncbi.nlm.nih.gov/pubmed/29973167
http://dx.doi.org/10.1186/s12889-018-5731-z
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