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Nuclear Klf4 accumulation is associated with cetuximab drug-resistance and predicts poor prognosis of nasopharyngeal carcinoma

BACKGROUND: The functions of the protein expressed in the nucleus and cytoplasm were different or opposite. The previous study found that oncogene Klf4 played a role of tumor suppressor in the nasopharyngeal cytoplasm. Cetuximab targeted epidermal growth factor receptor (EGFR) for the treatment of n...

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Detalles Bibliográficos
Autores principales:	Li, Xiqing, Zhao, Zunlan, Yi, Shijiang, Ma, Lei, Li, Ming, Liu, Mingyue, Zhang, Yaping, Liu, Guangzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2018
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030795/ https://www.ncbi.nlm.nih.gov/pubmed/29973197 http://dx.doi.org/10.1186/s12967-018-1561-0

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