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A critically ill patient after a colchicine overdose below the lethal dose: a case report

BACKGROUND: Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported. CASE PRESENTATION: An 18-year-old Japanese woman who had taken an overdose of prescription colchicine (1...

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Autores principales: Hirayama, Ichiro, Hiruma, Takahiro, Ueda, Yoshihiro, Doi, Kent, Morimura, Naoto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030797/
https://www.ncbi.nlm.nih.gov/pubmed/29970148
http://dx.doi.org/10.1186/s13256-018-1737-5
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author Hirayama, Ichiro
Hiruma, Takahiro
Ueda, Yoshihiro
Doi, Kent
Morimura, Naoto
author_facet Hirayama, Ichiro
Hiruma, Takahiro
Ueda, Yoshihiro
Doi, Kent
Morimura, Naoto
author_sort Hirayama, Ichiro
collection PubMed
description BACKGROUND: Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported. CASE PRESENTATION: An 18-year-old Japanese woman who had taken an overdose of prescription colchicine (15 mg; 0.2 mg/kg) was brought to our emergency out-patient department. Although her colchicine intake was below 0.8 mg/kg (considered the lethal dose), she reached a critical state and underwent three phases characterizing colchicine poisoning (gastrointestinal symptoms, multiple organ failure, and recovery). Her condition was critical, with a Sequential Organ Failure Assessment score of a maximum of 14. CONCLUSIONS: Patients might reach a critical stage after colchicine ingestion at a non-lethal dose. Thus, it might be necessary to review which dose of colchicine should be considered lethal.
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spelling pubmed-60307972018-07-09 A critically ill patient after a colchicine overdose below the lethal dose: a case report Hirayama, Ichiro Hiruma, Takahiro Ueda, Yoshihiro Doi, Kent Morimura, Naoto J Med Case Rep Case Report BACKGROUND: Although 0.8 mg/kg is considered a lethal dose of colchicine, fatal cases of patients who followed a critical disease course after an intake below this lethal dose have been reported. CASE PRESENTATION: An 18-year-old Japanese woman who had taken an overdose of prescription colchicine (15 mg; 0.2 mg/kg) was brought to our emergency out-patient department. Although her colchicine intake was below 0.8 mg/kg (considered the lethal dose), she reached a critical state and underwent three phases characterizing colchicine poisoning (gastrointestinal symptoms, multiple organ failure, and recovery). Her condition was critical, with a Sequential Organ Failure Assessment score of a maximum of 14. CONCLUSIONS: Patients might reach a critical stage after colchicine ingestion at a non-lethal dose. Thus, it might be necessary to review which dose of colchicine should be considered lethal. BioMed Central 2018-07-04 /pmc/articles/PMC6030797/ /pubmed/29970148 http://dx.doi.org/10.1186/s13256-018-1737-5 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Case Report
Hirayama, Ichiro
Hiruma, Takahiro
Ueda, Yoshihiro
Doi, Kent
Morimura, Naoto
A critically ill patient after a colchicine overdose below the lethal dose: a case report
title A critically ill patient after a colchicine overdose below the lethal dose: a case report
title_full A critically ill patient after a colchicine overdose below the lethal dose: a case report
title_fullStr A critically ill patient after a colchicine overdose below the lethal dose: a case report
title_full_unstemmed A critically ill patient after a colchicine overdose below the lethal dose: a case report
title_short A critically ill patient after a colchicine overdose below the lethal dose: a case report
title_sort critically ill patient after a colchicine overdose below the lethal dose: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030797/
https://www.ncbi.nlm.nih.gov/pubmed/29970148
http://dx.doi.org/10.1186/s13256-018-1737-5
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