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CircadiOmics: circadian omic web portal

Circadian rhythms play a fundamental role at all levels of biological organization. Understanding the mechanisms and implications of circadian oscillations continues to be the focus of intense research. However, there has been no comprehensive and integrated way for accessing and mining all circadia...

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Autores principales: Ceglia, Nicholas, Liu, Yu, Chen, Siwei, Agostinelli, Forest, Eckel-Mahan, Kristin, Sassone-Corsi, Paolo, Baldi, Pierre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030824/
https://www.ncbi.nlm.nih.gov/pubmed/29912458
http://dx.doi.org/10.1093/nar/gky441
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author Ceglia, Nicholas
Liu, Yu
Chen, Siwei
Agostinelli, Forest
Eckel-Mahan, Kristin
Sassone-Corsi, Paolo
Baldi, Pierre
author_facet Ceglia, Nicholas
Liu, Yu
Chen, Siwei
Agostinelli, Forest
Eckel-Mahan, Kristin
Sassone-Corsi, Paolo
Baldi, Pierre
author_sort Ceglia, Nicholas
collection PubMed
description Circadian rhythms play a fundamental role at all levels of biological organization. Understanding the mechanisms and implications of circadian oscillations continues to be the focus of intense research. However, there has been no comprehensive and integrated way for accessing and mining all circadian omic datasets. The latest release of CircadiOmics (http://circadiomics.ics.uci.edu) fills this gap for providing the most comprehensive web server for studying circadian data. The newly updated version contains high-throughput 227 omic datasets corresponding to over 74 million measurements sampled over 24 h cycles. Users can visualize and compare oscillatory trajectories across species, tissues and conditions. Periodicity statistics (e.g. period, amplitude, phase, P-value, q-value etc.) obtained from BIO_CYCLE and other methods are provided for all samples in the repository and can easily be downloaded in the form of publication-ready figures and tables. New features and substantial improvements in performance and data volume make CircadiOmics a powerful web portal for integrated analysis of circadian omic data.
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spelling pubmed-60308242018-07-10 CircadiOmics: circadian omic web portal Ceglia, Nicholas Liu, Yu Chen, Siwei Agostinelli, Forest Eckel-Mahan, Kristin Sassone-Corsi, Paolo Baldi, Pierre Nucleic Acids Res Web Server Issue Circadian rhythms play a fundamental role at all levels of biological organization. Understanding the mechanisms and implications of circadian oscillations continues to be the focus of intense research. However, there has been no comprehensive and integrated way for accessing and mining all circadian omic datasets. The latest release of CircadiOmics (http://circadiomics.ics.uci.edu) fills this gap for providing the most comprehensive web server for studying circadian data. The newly updated version contains high-throughput 227 omic datasets corresponding to over 74 million measurements sampled over 24 h cycles. Users can visualize and compare oscillatory trajectories across species, tissues and conditions. Periodicity statistics (e.g. period, amplitude, phase, P-value, q-value etc.) obtained from BIO_CYCLE and other methods are provided for all samples in the repository and can easily be downloaded in the form of publication-ready figures and tables. New features and substantial improvements in performance and data volume make CircadiOmics a powerful web portal for integrated analysis of circadian omic data. Oxford University Press 2018-07-02 2018-06-15 /pmc/articles/PMC6030824/ /pubmed/29912458 http://dx.doi.org/10.1093/nar/gky441 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Web Server Issue
Ceglia, Nicholas
Liu, Yu
Chen, Siwei
Agostinelli, Forest
Eckel-Mahan, Kristin
Sassone-Corsi, Paolo
Baldi, Pierre
CircadiOmics: circadian omic web portal
title CircadiOmics: circadian omic web portal
title_full CircadiOmics: circadian omic web portal
title_fullStr CircadiOmics: circadian omic web portal
title_full_unstemmed CircadiOmics: circadian omic web portal
title_short CircadiOmics: circadian omic web portal
title_sort circadiomics: circadian omic web portal
topic Web Server Issue
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030824/
https://www.ncbi.nlm.nih.gov/pubmed/29912458
http://dx.doi.org/10.1093/nar/gky441
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