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MetExplore: collaborative edition and exploration of metabolic networks
Metabolism of an organism is composed of hundreds to thousands of interconnected biochemical reactions responding to environmental or genetic constraints. This metabolic network provides a rich knowledge to contextualize omics data and to elaborate hypotheses on metabolic modulations. Nevertheless,...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030842/ https://www.ncbi.nlm.nih.gov/pubmed/29718355 http://dx.doi.org/10.1093/nar/gky301 |
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author | Cottret, Ludovic Frainay, Clément Chazalviel, Maxime Cabanettes, Floréal Gloaguen, Yoann Camenen, Etienne Merlet, Benjamin Heux, Stéphanie Portais, Jean-Charles Poupin, Nathalie Vinson, Florence Jourdan, Fabien |
author_facet | Cottret, Ludovic Frainay, Clément Chazalviel, Maxime Cabanettes, Floréal Gloaguen, Yoann Camenen, Etienne Merlet, Benjamin Heux, Stéphanie Portais, Jean-Charles Poupin, Nathalie Vinson, Florence Jourdan, Fabien |
author_sort | Cottret, Ludovic |
collection | PubMed |
description | Metabolism of an organism is composed of hundreds to thousands of interconnected biochemical reactions responding to environmental or genetic constraints. This metabolic network provides a rich knowledge to contextualize omics data and to elaborate hypotheses on metabolic modulations. Nevertheless, performing this kind of integrative analysis is challenging for end users with not sufficiently advanced computer skills since it requires the use of various tools and web servers. MetExplore offers an all-in-one online solution composed of interactive tools for metabolic network curation, network exploration and omics data analysis. In particular, it is possible to curate and annotate metabolic networks in a collaborative environment. The network exploration is also facilitated in MetExplore by a system of interactive tables connected to a powerful network visualization module. Finally, the contextualization of metabolic elements in the network and the calculation of over-representation statistics make it possible to interpret any kind of omics data. MetExplore is a sustainable project maintained since 2010 freely available at https://metexplore.toulouse.inra.fr/metexplore2/. |
format | Online Article Text |
id | pubmed-6030842 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Oxford University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-60308422018-07-10 MetExplore: collaborative edition and exploration of metabolic networks Cottret, Ludovic Frainay, Clément Chazalviel, Maxime Cabanettes, Floréal Gloaguen, Yoann Camenen, Etienne Merlet, Benjamin Heux, Stéphanie Portais, Jean-Charles Poupin, Nathalie Vinson, Florence Jourdan, Fabien Nucleic Acids Res Web Server Issue Metabolism of an organism is composed of hundreds to thousands of interconnected biochemical reactions responding to environmental or genetic constraints. This metabolic network provides a rich knowledge to contextualize omics data and to elaborate hypotheses on metabolic modulations. Nevertheless, performing this kind of integrative analysis is challenging for end users with not sufficiently advanced computer skills since it requires the use of various tools and web servers. MetExplore offers an all-in-one online solution composed of interactive tools for metabolic network curation, network exploration and omics data analysis. In particular, it is possible to curate and annotate metabolic networks in a collaborative environment. The network exploration is also facilitated in MetExplore by a system of interactive tables connected to a powerful network visualization module. Finally, the contextualization of metabolic elements in the network and the calculation of over-representation statistics make it possible to interpret any kind of omics data. MetExplore is a sustainable project maintained since 2010 freely available at https://metexplore.toulouse.inra.fr/metexplore2/. Oxford University Press 2018-07-02 2018-04-30 /pmc/articles/PMC6030842/ /pubmed/29718355 http://dx.doi.org/10.1093/nar/gky301 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Nucleic Acids Research. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com |
spellingShingle | Web Server Issue Cottret, Ludovic Frainay, Clément Chazalviel, Maxime Cabanettes, Floréal Gloaguen, Yoann Camenen, Etienne Merlet, Benjamin Heux, Stéphanie Portais, Jean-Charles Poupin, Nathalie Vinson, Florence Jourdan, Fabien MetExplore: collaborative edition and exploration of metabolic networks |
title | MetExplore: collaborative edition and exploration of metabolic networks |
title_full | MetExplore: collaborative edition and exploration of metabolic networks |
title_fullStr | MetExplore: collaborative edition and exploration of metabolic networks |
title_full_unstemmed | MetExplore: collaborative edition and exploration of metabolic networks |
title_short | MetExplore: collaborative edition and exploration of metabolic networks |
title_sort | metexplore: collaborative edition and exploration of metabolic networks |
topic | Web Server Issue |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030842/ https://www.ncbi.nlm.nih.gov/pubmed/29718355 http://dx.doi.org/10.1093/nar/gky301 |
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