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Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern

BACKGROUND: Late-life depression patients are at a high risk of developing Alzheimer’s disease, and diminished olfactory identification is an indicator in early screening for Alzheimer’s disease in the elderly. However, whether diminished olfactory identification is associated with risk of developin...

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Autores principales: Chen, Ben, Zhong, Xiaomei, Mai, Naikeng, Peng, Qi, Wu, Zhangying, Ouyang, Cong, Zhang, Weiru, Liang, Wanyuan, Wu, Yujie, Liu, Sha, Chen, Lijian, Ning, Yuping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030850/
https://www.ncbi.nlm.nih.gov/pubmed/29554341
http://dx.doi.org/10.1093/ijnp/pyy016
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author Chen, Ben
Zhong, Xiaomei
Mai, Naikeng
Peng, Qi
Wu, Zhangying
Ouyang, Cong
Zhang, Weiru
Liang, Wanyuan
Wu, Yujie
Liu, Sha
Chen, Lijian
Ning, Yuping
author_facet Chen, Ben
Zhong, Xiaomei
Mai, Naikeng
Peng, Qi
Wu, Zhangying
Ouyang, Cong
Zhang, Weiru
Liang, Wanyuan
Wu, Yujie
Liu, Sha
Chen, Lijian
Ning, Yuping
author_sort Chen, Ben
collection PubMed
description BACKGROUND: Late-life depression patients are at a high risk of developing Alzheimer’s disease, and diminished olfactory identification is an indicator in early screening for Alzheimer’s disease in the elderly. However, whether diminished olfactory identification is associated with risk of developing Alzheimer’s disease in late-life depression patients remains unclear. METHODS: One hundred and twenty-five late-life depression patients, 50 Alzheimer’s disease patients, and 60 normal controls were continuously recruited. The participants underwent a clinical evaluation, olfactory test, neuropsychological assessment, and neuroimaging assessment. RESULTS: The olfactory identification impairment in late-life depression patients was milder than that in Alzheimer’s disease patients. Diminished olfactory identification was significantly correlated with worse cognitive performance (global function, memory language, executive function, and attention) and reduced grey matter volume (olfactory bulb and hippocampus) in the late-life depression patients. According to a multiple linear regression analysis, olfactory identification was significantly associated with the memory scores in late-life depression group (B=1.623, P<.001). The late-life depression with olfactory identification impairment group had worse cognitive performance (global, memory, language, and executive function) and more structural abnormalities in Alzheimer’s disease-related regions than the late-life depression without olfactory identification impairment group, and global cognitive function and logical memory in the late-life depression without olfactory identification impairment group was intact. Reduced volume observed in many areas (hippocampus, precuneus, etc.) in the Alzheimer’s disease group was also observed in late-life depression with olfactory identification impairment group but not in the late-life depression without olfactory identification impairment group. CONCLUSION: The patterns of cognitive impairment and structural abnormalities in late-life depression with olfactory identification impairment patients were similar to those in Alzheimer’s disease; olfactory identification may help identify late-life depression patients who are at a high risk of developing Alzheimer’s disease.
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spelling pubmed-60308502018-07-10 Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern Chen, Ben Zhong, Xiaomei Mai, Naikeng Peng, Qi Wu, Zhangying Ouyang, Cong Zhang, Weiru Liang, Wanyuan Wu, Yujie Liu, Sha Chen, Lijian Ning, Yuping Int J Neuropsychopharmacol Regular Research Articles BACKGROUND: Late-life depression patients are at a high risk of developing Alzheimer’s disease, and diminished olfactory identification is an indicator in early screening for Alzheimer’s disease in the elderly. However, whether diminished olfactory identification is associated with risk of developing Alzheimer’s disease in late-life depression patients remains unclear. METHODS: One hundred and twenty-five late-life depression patients, 50 Alzheimer’s disease patients, and 60 normal controls were continuously recruited. The participants underwent a clinical evaluation, olfactory test, neuropsychological assessment, and neuroimaging assessment. RESULTS: The olfactory identification impairment in late-life depression patients was milder than that in Alzheimer’s disease patients. Diminished olfactory identification was significantly correlated with worse cognitive performance (global function, memory language, executive function, and attention) and reduced grey matter volume (olfactory bulb and hippocampus) in the late-life depression patients. According to a multiple linear regression analysis, olfactory identification was significantly associated with the memory scores in late-life depression group (B=1.623, P<.001). The late-life depression with olfactory identification impairment group had worse cognitive performance (global, memory, language, and executive function) and more structural abnormalities in Alzheimer’s disease-related regions than the late-life depression without olfactory identification impairment group, and global cognitive function and logical memory in the late-life depression without olfactory identification impairment group was intact. Reduced volume observed in many areas (hippocampus, precuneus, etc.) in the Alzheimer’s disease group was also observed in late-life depression with olfactory identification impairment group but not in the late-life depression without olfactory identification impairment group. CONCLUSION: The patterns of cognitive impairment and structural abnormalities in late-life depression with olfactory identification impairment patients were similar to those in Alzheimer’s disease; olfactory identification may help identify late-life depression patients who are at a high risk of developing Alzheimer’s disease. Oxford University Press 2018-03-15 /pmc/articles/PMC6030850/ /pubmed/29554341 http://dx.doi.org/10.1093/ijnp/pyy016 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of CINP. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Regular Research Articles
Chen, Ben
Zhong, Xiaomei
Mai, Naikeng
Peng, Qi
Wu, Zhangying
Ouyang, Cong
Zhang, Weiru
Liang, Wanyuan
Wu, Yujie
Liu, Sha
Chen, Lijian
Ning, Yuping
Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title_full Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title_fullStr Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title_full_unstemmed Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title_short Cognitive Impairment and Structural Abnormalities in Late Life Depression with Olfactory Identification Impairment: an Alzheimer’s Disease-Like Pattern
title_sort cognitive impairment and structural abnormalities in late life depression with olfactory identification impairment: an alzheimer’s disease-like pattern
topic Regular Research Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030850/
https://www.ncbi.nlm.nih.gov/pubmed/29554341
http://dx.doi.org/10.1093/ijnp/pyy016
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