Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population

BACKGROUND: Genetic changes in p53 gene contribute to breast cancer susceptibility. OBJECTIVE AND METHODS: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. RESULTS: p53 heterozygous arginine variant...

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Detalles Bibliográficos
Autores principales: Akhter, Naseem, Dar, Sajad A., Chattopadhyay, Shilpi, Haque, Shafiul, Anwer, Razique, Wahid, Mohd, Jawed, Arshad, Lohani, Mohtashim, Mandal, Raju K., Shukla, N. K., Abdul, Yasir, Husain, Syed Akhtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030857/
https://www.ncbi.nlm.nih.gov/pubmed/30065615
http://dx.doi.org/10.2174/1389202919666171205104137
Descripción
Sumario:BACKGROUND: Genetic changes in p53 gene contribute to breast cancer susceptibility. OBJECTIVE AND METHODS: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. RESULTS: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. CONCLUSION: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.

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