Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population

BACKGROUND: Genetic changes in p53 gene contribute to breast cancer susceptibility. OBJECTIVE AND METHODS: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. RESULTS: p53 heterozygous arginine variant...

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Autores principales: Akhter, Naseem, Dar, Sajad A., Chattopadhyay, Shilpi, Haque, Shafiul, Anwer, Razique, Wahid, Mohd, Jawed, Arshad, Lohani, Mohtashim, Mandal, Raju K., Shukla, N. K., Abdul, Yasir, Husain, Syed Akhtar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2018
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030857/
https://www.ncbi.nlm.nih.gov/pubmed/30065615
http://dx.doi.org/10.2174/1389202919666171205104137
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author Akhter, Naseem
Dar, Sajad A.
Chattopadhyay, Shilpi
Haque, Shafiul
Anwer, Razique
Wahid, Mohd
Jawed, Arshad
Lohani, Mohtashim
Mandal, Raju K.
Shukla, N. K.
Abdul, Yasir
Husain, Syed Akhtar
author_facet Akhter, Naseem
Dar, Sajad A.
Chattopadhyay, Shilpi
Haque, Shafiul
Anwer, Razique
Wahid, Mohd
Jawed, Arshad
Lohani, Mohtashim
Mandal, Raju K.
Shukla, N. K.
Abdul, Yasir
Husain, Syed Akhtar
author_sort Akhter, Naseem
collection PubMed
description BACKGROUND: Genetic changes in p53 gene contribute to breast cancer susceptibility. OBJECTIVE AND METHODS: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. RESULTS: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. CONCLUSION: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population.
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spelling pubmed-60308572019-02-01 Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population Akhter, Naseem Dar, Sajad A. Chattopadhyay, Shilpi Haque, Shafiul Anwer, Razique Wahid, Mohd Jawed, Arshad Lohani, Mohtashim Mandal, Raju K. Shukla, N. K. Abdul, Yasir Husain, Syed Akhtar Curr Genomics Article BACKGROUND: Genetic changes in p53 gene contribute to breast cancer susceptibility. OBJECTIVE AND METHODS: A case-control study and a meta-analysis were performed to investigate the role of p53 codon72 SNP with breast cancer susceptibility in Indian women. RESULTS: p53 heterozygous arginine variant was associated with decreased risk of breast cancer in total cohort. In meta-analysis, Allelic and GG vs. CC genetic comparison model were found to be associated with breast cancer risk. Moreover, recessive comparison model indicated a protective correlation with breast cancer occurrence. CONCLUSION: The findings of our case-control study and meta-analysis suggest a significant association between p53 Arg72Pro polymorphism and an increased risk of breast cancer in Indian population. Bentham Science Publishers 2018-08 2018-08 /pmc/articles/PMC6030857/ /pubmed/30065615 http://dx.doi.org/10.2174/1389202919666171205104137 Text en © 2018 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/legalcode This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Akhter, Naseem
Dar, Sajad A.
Chattopadhyay, Shilpi
Haque, Shafiul
Anwer, Razique
Wahid, Mohd
Jawed, Arshad
Lohani, Mohtashim
Mandal, Raju K.
Shukla, N. K.
Abdul, Yasir
Husain, Syed Akhtar
Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title_full Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title_fullStr Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title_full_unstemmed Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title_short Impact of p53 arg72pro SNP on Breast Cancer Risk in North Indian Population
title_sort impact of p53 arg72pro snp on breast cancer risk in north indian population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030857/
https://www.ncbi.nlm.nih.gov/pubmed/30065615
http://dx.doi.org/10.2174/1389202919666171205104137
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