Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection

Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)–related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infect...

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Autores principales: Naggie, Susanna, Swiderska-Syn, Marzena, Choi, Steve, Lusk, Sam, Lan, Audrey, Ferrari, Guido, Syn, Wing-Kin, Guy, Cynthia D, Diehl, Anna Mae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2018
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030967/
https://www.ncbi.nlm.nih.gov/pubmed/29992177
http://dx.doi.org/10.1093/ofid/ofy138
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author Naggie, Susanna
Swiderska-Syn, Marzena
Choi, Steve
Lusk, Sam
Lan, Audrey
Ferrari, Guido
Syn, Wing-Kin
Guy, Cynthia D
Diehl, Anna Mae
author_facet Naggie, Susanna
Swiderska-Syn, Marzena
Choi, Steve
Lusk, Sam
Lan, Audrey
Ferrari, Guido
Syn, Wing-Kin
Guy, Cynthia D
Diehl, Anna Mae
author_sort Naggie, Susanna
collection PubMed
description Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)–related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue.
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spelling pubmed-60309672018-07-10 Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection Naggie, Susanna Swiderska-Syn, Marzena Choi, Steve Lusk, Sam Lan, Audrey Ferrari, Guido Syn, Wing-Kin Guy, Cynthia D Diehl, Anna Mae Open Forum Infect Dis Brief Report Liver disease is a leading cause of HIV-related mortality. Hepatitis C virus (HCV)–related fibrogenesis is accelerated in the setting of HIV coinfection, yet the mechanisms underlying this aggressive pathogenesis are unclear. We identified formalin-fixed paraffin-embedded liver tissue for HIV-infected patients, HCV-infected patients, HIV/HCV-coinfected patients, and controls at Duke University Medical Center. De-identified sections were stained for markers against the wound repair Hedgehog (Hh) pathway, resident T-lymphocytes, and immune activation and cellular aging. HIV infection was independently associated with Hh activation and markers of immune dysregulation in the liver tissue. Oxford University Press 2018-06-11 /pmc/articles/PMC6030967/ /pubmed/29992177 http://dx.doi.org/10.1093/ofid/ofy138 Text en © The Author(s) 2018. Published by Oxford University Press on behalf of Infectious Diseases Society of America. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Brief Report
Naggie, Susanna
Swiderska-Syn, Marzena
Choi, Steve
Lusk, Sam
Lan, Audrey
Ferrari, Guido
Syn, Wing-Kin
Guy, Cynthia D
Diehl, Anna Mae
Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title_full Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title_fullStr Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title_full_unstemmed Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title_short Markers of Tissue Repair and Cellular Aging Are Increased in the Liver Tissue of Patients With HIV Infection Regardless of Presence of HCV Coinfection
title_sort markers of tissue repair and cellular aging are increased in the liver tissue of patients with hiv infection regardless of presence of hcv coinfection
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6030967/
https://www.ncbi.nlm.nih.gov/pubmed/29992177
http://dx.doi.org/10.1093/ofid/ofy138
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