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Is there a relationship between fetal sex and placental pathological characteristics in twin gestations?
BACKGROUND: Placenta plays a central role in mediating growth and development of fetuses. Sex-specific placentas may complicate this role. METHODS: The study aimed at investigating the association between fetal sex and placental pathological findings in twin gestations using generalized estimating e...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031115/ https://www.ncbi.nlm.nih.gov/pubmed/29973164 http://dx.doi.org/10.1186/s12884-018-1896-9 |
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author | Jahanfar, Shayesteh Lim, Kenneth |
author_facet | Jahanfar, Shayesteh Lim, Kenneth |
author_sort | Jahanfar, Shayesteh |
collection | PubMed |
description | BACKGROUND: Placenta plays a central role in mediating growth and development of fetuses. Sex-specific placentas may complicate this role. METHODS: The study aimed at investigating the association between fetal sex and placental pathological findings in twin gestations using generalized estimating equation modeling. We used a large population-based clinical data born in British Columbia (BC) and linked the fetal-maternal data to hand-searched pathology reports of 1493 twin placentas from twins born in BC Women hospital. We analyzed the data using generalized estimating equations taking the cluster nature of twins into consideration. RESULTS: About 26.5% of twins were monochorionic and 73.5% were dizygotic. Most twins were male (51.3%). About 2/3 of twins were sex concordant (66.6%). Of the sex concordant twins, similar percentages were male-male (34.7%) and female-female (31.2%). Of the sex discordant twins, the male-female (33.3%) group constituted about 1/3 of the whole population. Adjusted for chorionicity, birth weight discordance ≥30% and gestational age, the odds of chorionitis (1.38, 95% CI = 1.04–1.84), anastomosis (1.63, 95% CI = 1.22–2.19), unequal sharing of placenta (1.72, 95% CI = 1.11–2.64), placental inflammation (1.30, 95% CI = 1.05–1.62) and lesions (1.83, 95% CI = 1.02–3.31) were higher in male twins compared with females. Twins of either sex from sex-discordant pairs were less likely to have placental anastomosis compared to the reference category. Males from male-male pairs had higher odds of unequal placental sharing (74% higher) and composite inflammation (52% higher) compared with the reference twins. CONCLUSION: Our findings suggest a relationship between sex and placental pathological results. |
format | Online Article Text |
id | pubmed-6031115 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-60311152018-07-11 Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? Jahanfar, Shayesteh Lim, Kenneth BMC Pregnancy Childbirth Research Article BACKGROUND: Placenta plays a central role in mediating growth and development of fetuses. Sex-specific placentas may complicate this role. METHODS: The study aimed at investigating the association between fetal sex and placental pathological findings in twin gestations using generalized estimating equation modeling. We used a large population-based clinical data born in British Columbia (BC) and linked the fetal-maternal data to hand-searched pathology reports of 1493 twin placentas from twins born in BC Women hospital. We analyzed the data using generalized estimating equations taking the cluster nature of twins into consideration. RESULTS: About 26.5% of twins were monochorionic and 73.5% were dizygotic. Most twins were male (51.3%). About 2/3 of twins were sex concordant (66.6%). Of the sex concordant twins, similar percentages were male-male (34.7%) and female-female (31.2%). Of the sex discordant twins, the male-female (33.3%) group constituted about 1/3 of the whole population. Adjusted for chorionicity, birth weight discordance ≥30% and gestational age, the odds of chorionitis (1.38, 95% CI = 1.04–1.84), anastomosis (1.63, 95% CI = 1.22–2.19), unequal sharing of placenta (1.72, 95% CI = 1.11–2.64), placental inflammation (1.30, 95% CI = 1.05–1.62) and lesions (1.83, 95% CI = 1.02–3.31) were higher in male twins compared with females. Twins of either sex from sex-discordant pairs were less likely to have placental anastomosis compared to the reference category. Males from male-male pairs had higher odds of unequal placental sharing (74% higher) and composite inflammation (52% higher) compared with the reference twins. CONCLUSION: Our findings suggest a relationship between sex and placental pathological results. BioMed Central 2018-07-04 /pmc/articles/PMC6031115/ /pubmed/29973164 http://dx.doi.org/10.1186/s12884-018-1896-9 Text en © The Author(s). 2018 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. |
spellingShingle | Research Article Jahanfar, Shayesteh Lim, Kenneth Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title | Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title_full | Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title_fullStr | Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title_full_unstemmed | Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title_short | Is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
title_sort | is there a relationship between fetal sex and placental pathological characteristics in twin gestations? |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031115/ https://www.ncbi.nlm.nih.gov/pubmed/29973164 http://dx.doi.org/10.1186/s12884-018-1896-9 |
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