A large-scale whole-genome sequencing analysis reveals highly specific genome editing by both Cas9 and Cpf1 (Cas12a) nucleases in rice

BACKGROUND: Targeting specificity has been a barrier to applying genome editing systems in functional genomics, precise medicine and plant breeding. In plants, only limited studies have used whole-genome sequencing (WGS) to test off-target effects of Cas9. The cause of numerous discovered mutations...

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Detalles Bibliográficos
Autores principales: Tang, Xu, Liu, Guanqing, Zhou, Jianping, Ren, Qiurong, You, Qi, Tian, Li, Xin, Xuhui, Zhong, Zhaohui, Liu, Binglin, Zheng, Xuelian, Zhang, Dengwei, Malzahn, Aimee, Gong, Zhiyun, Qi, Yiping, Zhang, Tao, Zhang, Yong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2018
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031188/
https://www.ncbi.nlm.nih.gov/pubmed/29973285
http://dx.doi.org/10.1186/s13059-018-1458-5

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