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Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants

We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extracts. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH) and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI...

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Autores principales: Jamous, Rana M., Abu-Zaitoun, Salam Y., Akkawi, Rola J., Ali-Shtayeh, Mohammed S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031216/
https://www.ncbi.nlm.nih.gov/pubmed/30026782
http://dx.doi.org/10.1155/2018/8426752
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author Jamous, Rana M.
Abu-Zaitoun, Salam Y.
Akkawi, Rola J.
Ali-Shtayeh, Mohammed S.
author_facet Jamous, Rana M.
Abu-Zaitoun, Salam Y.
Akkawi, Rola J.
Ali-Shtayeh, Mohammed S.
author_sort Jamous, Rana M.
collection PubMed
description We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extracts. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH) and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI activity of plant extracts. Among the 90 plant extracts examined, 41.0 % crude extracts showed antilipase activity of more than 50%. The most active plants by means of IC(50) value were Camellia sinensis (0.5 mg/ml), Ceratonia siliqua (leaves) (0.8 mg/mL), Curcuma longa (0.8 mg/mL), Sarcopoterium spinosum (1.2 mg/mL), and Mentha spicata (1.2 mg/mL). The antioxidant activity of plant extracts using the DPPH and RP assays reveals comparable results. The most active antioxidant extracts using both assays were the leaves and fruit epicarp of Rhus coriaria, areal parts of Sarcopoterium spinosum, and leaves of Ceratonia siliqua. Our results suggest natural resources that possess strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight. The extracts of Camellia sinensis, Ceratonia siliqua, Curcuma longa, Sarcopoterium spinosum, and Mentha spicata were proved to have a great potential as antioxidants and antiobesity agents.
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spelling pubmed-60312162018-07-19 Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants Jamous, Rana M. Abu-Zaitoun, Salam Y. Akkawi, Rola J. Ali-Shtayeh, Mohammed S. Evid Based Complement Alternat Med Research Article We evaluated the antioxidant and porcine pancreatic lipase inhibition (PPLI) activities of 90 plants extracts. The antioxidant activity was measured using the free-radical scavenging capacity (DPPH) and reducing power (RP) assays. The pancreatic lipase inhibition assay was used to determine the PPLI activity of plant extracts. Among the 90 plant extracts examined, 41.0 % crude extracts showed antilipase activity of more than 50%. The most active plants by means of IC(50) value were Camellia sinensis (0.5 mg/ml), Ceratonia siliqua (leaves) (0.8 mg/mL), Curcuma longa (0.8 mg/mL), Sarcopoterium spinosum (1.2 mg/mL), and Mentha spicata (1.2 mg/mL). The antioxidant activity of plant extracts using the DPPH and RP assays reveals comparable results. The most active antioxidant extracts using both assays were the leaves and fruit epicarp of Rhus coriaria, areal parts of Sarcopoterium spinosum, and leaves of Ceratonia siliqua. Our results suggest natural resources that possess strong antioxidant and pancreatic lipase inhibitory activities with potential applications in the treatment and prevention of obesity and overweight. The extracts of Camellia sinensis, Ceratonia siliqua, Curcuma longa, Sarcopoterium spinosum, and Mentha spicata were proved to have a great potential as antioxidants and antiobesity agents. Hindawi 2018-06-13 /pmc/articles/PMC6031216/ /pubmed/30026782 http://dx.doi.org/10.1155/2018/8426752 Text en Copyright © 2018 Rana M. Jamous et al. https://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Jamous, Rana M.
Abu-Zaitoun, Salam Y.
Akkawi, Rola J.
Ali-Shtayeh, Mohammed S.
Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title_full Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title_fullStr Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title_full_unstemmed Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title_short Antiobesity and Antioxidant Potentials of Selected Palestinian Medicinal Plants
title_sort antiobesity and antioxidant potentials of selected palestinian medicinal plants
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031216/
https://www.ncbi.nlm.nih.gov/pubmed/30026782
http://dx.doi.org/10.1155/2018/8426752
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