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Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review

BACKGROUND: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesion...

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Autores principales: Zeng, Jianfeng, Wang, Shanyun, Zhong, Liang, Huang, Zhifeng, Zeng, Ye, Wu, Song, Zheng, Dongxiang, Zou, Weiwei, Lai, Haibiao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031250/
https://www.ncbi.nlm.nih.gov/pubmed/29977425
http://dx.doi.org/10.14740/jocmr3500w
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author Zeng, Jianfeng
Wang, Shanyun
Zhong, Liang
Huang, Zhifeng
Zeng, Ye
Wu, Song
Zheng, Dongxiang
Zou, Weiwei
Lai, Haibiao
author_facet Zeng, Jianfeng
Wang, Shanyun
Zhong, Liang
Huang, Zhifeng
Zeng, Ye
Wu, Song
Zheng, Dongxiang
Zou, Weiwei
Lai, Haibiao
author_sort Zeng, Jianfeng
collection PubMed
description BACKGROUND: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesions in the urethra, and bloody drainage from the urethral meatus is often seen during physical exams. METHODS: A 52-year-old woman presented with dysuria for 6 months. Urethrocystoscopy did not reveal abnormality, and there was no bloody vaginal drainage or bloody drainage from the urethral meatus during physical exams. Ultrasonography demonstrated a solid mass with well-defined margins located between the anterior vaginal wall and the posterior urethral wall. Computed tomography showed the mass with smooth margins at the level of vaginal fornix, and magnetic resonance imaging showed the same location of the tumor as ultrasonography. RESULTS: Surgical removal of the tumor was successfully performed and histological and immunohistochemical analysis confirmed the final diagnosis of CCAU. CONCLUSION: Abnormality in urethrocystoscopy and bloody drainage during the physical exam were not found in this case, which is in contrast to the findings reported in literature. These unusual features add new knowledge about CCAU that deserves dissemination for improved CCAU diagnosis and management.
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spelling pubmed-60312502018-07-05 Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review Zeng, Jianfeng Wang, Shanyun Zhong, Liang Huang, Zhifeng Zeng, Ye Wu, Song Zheng, Dongxiang Zou, Weiwei Lai, Haibiao J Clin Med Res Case Report BACKGROUND: There has been scarce information about clear cell adenocarcinoma of the urethra (CCAU), an extremely rare type of cancer. A few case reports show that CCAU tends to have similar clinical manifestation to the other urethral carcinomas, urethrocystoscopy can easily identify tumoral lesions in the urethra, and bloody drainage from the urethral meatus is often seen during physical exams. METHODS: A 52-year-old woman presented with dysuria for 6 months. Urethrocystoscopy did not reveal abnormality, and there was no bloody vaginal drainage or bloody drainage from the urethral meatus during physical exams. Ultrasonography demonstrated a solid mass with well-defined margins located between the anterior vaginal wall and the posterior urethral wall. Computed tomography showed the mass with smooth margins at the level of vaginal fornix, and magnetic resonance imaging showed the same location of the tumor as ultrasonography. RESULTS: Surgical removal of the tumor was successfully performed and histological and immunohistochemical analysis confirmed the final diagnosis of CCAU. CONCLUSION: Abnormality in urethrocystoscopy and bloody drainage during the physical exam were not found in this case, which is in contrast to the findings reported in literature. These unusual features add new knowledge about CCAU that deserves dissemination for improved CCAU diagnosis and management. Elmer Press 2018-08 2018-06-27 /pmc/articles/PMC6031250/ /pubmed/29977425 http://dx.doi.org/10.14740/jocmr3500w Text en Copyright 2018, Lai et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Zeng, Jianfeng
Wang, Shanyun
Zhong, Liang
Huang, Zhifeng
Zeng, Ye
Wu, Song
Zheng, Dongxiang
Zou, Weiwei
Lai, Haibiao
Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title_full Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title_fullStr Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title_full_unstemmed Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title_short Unusual Features of Clear Cell Adenocarcinoma of the Female Urethra: A Case Report and Literature Review
title_sort unusual features of clear cell adenocarcinoma of the female urethra: a case report and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031250/
https://www.ncbi.nlm.nih.gov/pubmed/29977425
http://dx.doi.org/10.14740/jocmr3500w
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