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RNaseT2 knockout rats exhibit hippocampal neuropathology and deficits in memory

RNASET2 deficiency in humans is associated with infant cystic leukoencephalopathy, which causes psychomotor impairment, spasticity and epilepsy. A zebrafish mutant model suggests that loss of RNASET2 function leads to neurodegeneration due to the accumulation of non-degraded RNA in the lysosomes. Th...

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Detalles Bibliográficos
Autores principales:	Sinkevicius, Kerstin W., Morrison, Thomas R., Kulkarni, Praveen, Caffrey Cagliostro, Martha K., Iriah, Sade, Malmberg, Samantha, Sabrick, Julia, Honeycutt, Jennifer A., Askew, Kim L., Trivedi, Malav, Ferris, Craig F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031352/ https://www.ncbi.nlm.nih.gov/pubmed/29752287 http://dx.doi.org/10.1242/dmm.032631

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