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Epigenetic regulators Rbbp4 and Hdac1 are overexpressed in a zebrafish model of RB1 embryonal brain tumor, and are required for neural progenitor survival and proliferation

In this study, we used comparative genomics and developmental genetics to identify epigenetic regulators driving oncogenesis in a zebrafish retinoblastoma 1 (rb1) somatic-targeting model of RB1 mutant embryonal brain tumors. Zebrafish rb1 brain tumors caused by TALEN or CRISPR targeting are histolog...

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Detalles Bibliográficos
Autores principales:	Schultz, Laura E., Haltom, Jeffrey A., Almeida, Maira P., Wierson, Wesley A., Solin, Staci L., Weiss, Trevor J., Helmer, Jordan A., Sandquist, Elizabeth J., Shive, Heather R., McGrail, Maura
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Ltd 2018
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031359/ https://www.ncbi.nlm.nih.gov/pubmed/29914980 http://dx.doi.org/10.1242/dmm.034124

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