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Structures of two aptamers with differing ligand specificity reveal ruggedness in the functional landscape of RNA

Two classes of riboswitches related to the ykkC guanidine-I riboswitch bind phosphoribosyl pyrophosphate (PRPP) and guanosine tetraphosphate (ppGpp). Here we report the co-crystal structure of the PRPP aptamer and its ligand. We also report the structure of the G96A point mutant that prefers ppGpp o...

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Detalles Bibliográficos
Autores principales:	Knappenberger, Andrew John, Reiss, Caroline Wetherington, Strobel, Scott A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2018
Materias:	Structural Biology and Molecular Biophysics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031431/ https://www.ncbi.nlm.nih.gov/pubmed/29877798 http://dx.doi.org/10.7554/eLife.36381

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