Mechanisms of metformin action: In and out of the gut

Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of (18)F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affect...

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Detalles Bibliográficos
Autores principales: Minamii, Takahiro, Nogami, Munenobu, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031513/
https://www.ncbi.nlm.nih.gov/pubmed/29777629
http://dx.doi.org/10.1111/jdi.12864
Descripción
Sumario:Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of (18)F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affects the handling of glucose in colon whereas the underlying mechanism and the significance to glucose metabolism of the finding remain to be determined. [Image: see text]

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