Mechanisms of metformin action: In and out of the gut

Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of (18)F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affect...

Descripción completa

Detalles Bibliográficos
Autores principales: Minamii, Takahiro, Nogami, Munenobu, Ogawa, Wataru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Editorial
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031513/
https://www.ncbi.nlm.nih.gov/pubmed/29777629
http://dx.doi.org/10.1111/jdi.12864
_version_ 1783337327563636736
author Minamii, Takahiro
Nogami, Munenobu
Ogawa, Wataru
author_facet Minamii, Takahiro
Nogami, Munenobu
Ogawa, Wataru
author_sort Minamii, Takahiro
collection PubMed
description Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of (18)F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affects the handling of glucose in colon whereas the underlying mechanism and the significance to glucose metabolism of the finding remain to be determined. [Image: see text]
format Online
Article
Text
id pubmed-6031513
institution National Center for Biotechnology Information
language English
publishDate 2018
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-60315132018-07-11 Mechanisms of metformin action: In and out of the gut Minamii, Takahiro Nogami, Munenobu Ogawa, Wataru J Diabetes Investig Editorial Recent evidence suggests that metformin exerts glucose‐lowering effects via its action in the gut. The accumulation in the colon of (18)F‐labeled fluorodeoxyglucose (FDG), a nonmetabolizable derivative of glucose, is markedly augmented after metformin administration, indicating that metformin affects the handling of glucose in colon whereas the underlying mechanism and the significance to glucose metabolism of the finding remain to be determined. [Image: see text] John Wiley and Sons Inc. 2018-06-05 2018-07 /pmc/articles/PMC6031513/ /pubmed/29777629 http://dx.doi.org/10.1111/jdi.12864 Text en © 2018 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
spellingShingle Editorial
Minamii, Takahiro
Nogami, Munenobu
Ogawa, Wataru
Mechanisms of metformin action: In and out of the gut
title Mechanisms of metformin action: In and out of the gut
title_full Mechanisms of metformin action: In and out of the gut
title_fullStr Mechanisms of metformin action: In and out of the gut
title_full_unstemmed Mechanisms of metformin action: In and out of the gut
title_short Mechanisms of metformin action: In and out of the gut
title_sort mechanisms of metformin action: in and out of the gut
topic Editorial
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031513/
https://www.ncbi.nlm.nih.gov/pubmed/29777629
http://dx.doi.org/10.1111/jdi.12864
work_keys_str_mv AT minamiitakahiro mechanismsofmetforminactioninandoutofthegut
AT nogamimunenobu mechanismsofmetforminactioninandoutofthegut
AT ogawawataru mechanismsofmetforminactioninandoutofthegut

Ejemplares similares