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Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review

Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely....

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Autores principales: Choi, Jae-Ki, Cho, Sung-Yeon, Choi, Su-Mi, Kim, Gyo Hui, Lee, Sung-Eun, Lee, Seok, Kim, Dong-Wook, Lee, Dong-Gun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031599/
https://www.ncbi.nlm.nih.gov/pubmed/29968984
http://dx.doi.org/10.3947/ic.2018.50.2.153
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author Choi, Jae-Ki
Cho, Sung-Yeon
Choi, Su-Mi
Kim, Gyo Hui
Lee, Sung-Eun
Lee, Seok
Kim, Dong-Wook
Lee, Dong-Gun
author_facet Choi, Jae-Ki
Cho, Sung-Yeon
Choi, Su-Mi
Kim, Gyo Hui
Lee, Sung-Eun
Lee, Seok
Kim, Dong-Wook
Lee, Dong-Gun
author_sort Choi, Jae-Ki
collection PubMed
description Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib.
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spelling pubmed-60315992018-07-07 Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review Choi, Jae-Ki Cho, Sung-Yeon Choi, Su-Mi Kim, Gyo Hui Lee, Sung-Eun Lee, Seok Kim, Dong-Wook Lee, Dong-Gun Infect Chemother Case Report Dasatinib, a tyrosine kinase inhibitor, is widely used for patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia. Although the drug has a potent immunosuppressive effect, infectious complications during dasatinib treatment have been reported rarely. We describe five patients who developed cytomegalovirus (CMV) colitis during dasatinib treatment, in whom the colitis was initially confused with other causes. The patients, three with chronic myeloid leukemia, and two with acute lymphoblastic leukemia, were diagnosed with CMV colitis based on endoscopic and histologic findings. The patients who examined blood CMV polymerase chain reaction were all positive. The patients received antiviral therapy in the form of either ganciclovir or valganciclovir, and the overall treatment outcome was fair. These cases suggest that physicians should consider the possibility of CMV reactivation when treating diarrhea and/or hematochezia in patients on dasatinib. The Korean Society of Infectious Diseases and Korean Society for Chemotherapy 2018-06 2018-06-08 /pmc/articles/PMC6031599/ /pubmed/29968984 http://dx.doi.org/10.3947/ic.2018.50.2.153 Text en Copyright © 2018 by The Korean Society of Infectious Diseases and Korean Society for Chemotherapy http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Choi, Jae-Ki
Cho, Sung-Yeon
Choi, Su-Mi
Kim, Gyo Hui
Lee, Sung-Eun
Lee, Seok
Kim, Dong-Wook
Lee, Dong-Gun
Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title_full Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title_fullStr Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title_full_unstemmed Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title_short Cytomegalovirus Colitis during Dasatinib Treatment for Patients with Hematologic Malignancy: Case Series and Literature Review
title_sort cytomegalovirus colitis during dasatinib treatment for patients with hematologic malignancy: case series and literature review
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031599/
https://www.ncbi.nlm.nih.gov/pubmed/29968984
http://dx.doi.org/10.3947/ic.2018.50.2.153
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