CTLA-4 +49 G/A, a functional T1D risk SNP, affects CTLA-4 level in Treg subsets and IA-2A positivity, but not beta-cell function

To investigate whether CTLA-4 +49 G/A (rs231775), a tagSNP in Asian, is a functional T1D SNP, we genotyped this SNP with 1035 T1D patients and 2575 controls in Chinese Han population. And 1280 controls measured insulin release and sensitivity based on an oral glucose tolerance test; 283 newly diagno...

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Detalles Bibliográficos
Autores principales: Chen, Yang, Chen, Shu, Gu, Yong, Feng, Yingjie, Shi, Yun, Fu, Qi, Wang, Zhixiao, Cai, Yun, Dai, Hao, Zheng, Shuai, Sun, Min, Zhang, Mei, Xu, Xinyu, Chen, Heng, Xu, Kuanfeng, Yang, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031668/
https://www.ncbi.nlm.nih.gov/pubmed/29973665
http://dx.doi.org/10.1038/s41598-018-28423-9

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