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Dissecting Distinct Roles of NEDDylation E1 Ligase Heterodimer APPBP1 and UBA3 Reveals Potential Evolution Process for Activation of Ubiquitin-related Pathways

Despite the similar enzyme cascade in the Ubiquitin and Ubiquitin-like peptide(Ubl) conjugation, the involvement of single or heterodimer E1 activating enzyme has been a mystery. Here, by using a quantitative Förster Resonance Energy Transfer (FRET) technology, aided with Analysis of Electrostatic S...

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Detalles Bibliográficos
Autores principales:	Malik-Chaudhry, Harbani Kaur, Gaieb, Zied, Saavedra, Amanda, Reyes, Michael, Kung, Raphael, Le, Frank, Morikis, Dimitrios, Liao, Jiayu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031683/ https://www.ncbi.nlm.nih.gov/pubmed/29973603 http://dx.doi.org/10.1038/s41598-018-28214-2

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