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The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma

Our study aimed to investigate the association between metabolic syndrome and postoperative survival in patients with esophageal squamous cell carcinoma, and evaluate whether metabolic syndrome can predict the prognosis in esophageal cancer patients. The retrospective study reviewed 519 patients wit...

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Detalles Bibliográficos
Autores principales: Liu, Bowen, Cheng, Bo, Wang, Cong, Chen, Pengxiang, Cheng, Yufeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031687/
https://www.ncbi.nlm.nih.gov/pubmed/29973636
http://dx.doi.org/10.1038/s41598-018-28268-2
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author Liu, Bowen
Cheng, Bo
Wang, Cong
Chen, Pengxiang
Cheng, Yufeng
author_facet Liu, Bowen
Cheng, Bo
Wang, Cong
Chen, Pengxiang
Cheng, Yufeng
author_sort Liu, Bowen
collection PubMed
description Our study aimed to investigate the association between metabolic syndrome and postoperative survival in patients with esophageal squamous cell carcinoma, and evaluate whether metabolic syndrome can predict the prognosis in esophageal cancer patients. The retrospective study reviewed 519 patients with esophageal squamous cell carcinoma who had received esophagetomy and lymphnode dissections in the Department of Thoracic Surgery, Qilu Hospital of Shandong University between January 2007 and December 2011. All patients were followed up until December 2016. The median follow-up time was 39.59 months (range 0.25–72 months). The 3-year and 5-year survival rate was 51.4% and 37.0%, respectively. Kaplan–Meier survival analysis revealed a significant correlation between OS and obesity (P = 0.000), weight loss (P = 0.000), diabetes (P = 0.001) and dyslipidemia (P = 0.030). Multivariate analysis indicated that advanced TNM staging (P = 0.007, HR: 1.760, 95% CI: 1.167–2.654) and more weight loss (P = 0.000, HR: 1.961, 95% CI: 1.697–2.267) were independent factors for adverse prognosis of esophageal squamous carcinoma patients. In contrast, diabetes was a protective factor in the prognosis of patients with esophageal cancer (P = 0.018, HR: 0.668, 95% CI: 0.478–0.933). Our findings suggest that TNM staging, weight changes and diabetes were independent predictors for the prognosis of esophageal cancer patients.
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spelling pubmed-60316872018-07-12 The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma Liu, Bowen Cheng, Bo Wang, Cong Chen, Pengxiang Cheng, Yufeng Sci Rep Article Our study aimed to investigate the association between metabolic syndrome and postoperative survival in patients with esophageal squamous cell carcinoma, and evaluate whether metabolic syndrome can predict the prognosis in esophageal cancer patients. The retrospective study reviewed 519 patients with esophageal squamous cell carcinoma who had received esophagetomy and lymphnode dissections in the Department of Thoracic Surgery, Qilu Hospital of Shandong University between January 2007 and December 2011. All patients were followed up until December 2016. The median follow-up time was 39.59 months (range 0.25–72 months). The 3-year and 5-year survival rate was 51.4% and 37.0%, respectively. Kaplan–Meier survival analysis revealed a significant correlation between OS and obesity (P = 0.000), weight loss (P = 0.000), diabetes (P = 0.001) and dyslipidemia (P = 0.030). Multivariate analysis indicated that advanced TNM staging (P = 0.007, HR: 1.760, 95% CI: 1.167–2.654) and more weight loss (P = 0.000, HR: 1.961, 95% CI: 1.697–2.267) were independent factors for adverse prognosis of esophageal squamous carcinoma patients. In contrast, diabetes was a protective factor in the prognosis of patients with esophageal cancer (P = 0.018, HR: 0.668, 95% CI: 0.478–0.933). Our findings suggest that TNM staging, weight changes and diabetes were independent predictors for the prognosis of esophageal cancer patients. Nature Publishing Group UK 2018-07-04 /pmc/articles/PMC6031687/ /pubmed/29973636 http://dx.doi.org/10.1038/s41598-018-28268-2 Text en © The Author(s) 2018 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Liu, Bowen
Cheng, Bo
Wang, Cong
Chen, Pengxiang
Cheng, Yufeng
The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title_full The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title_fullStr The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title_full_unstemmed The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title_short The prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
title_sort prognostic significance of metabolic syndrome and weight loss in esophageal squamous cell carcinoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031687/
https://www.ncbi.nlm.nih.gov/pubmed/29973636
http://dx.doi.org/10.1038/s41598-018-28268-2
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