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microRNA-122 amplifies hepatitis C virus translation by shaping the structure of the internal ribosomal entry site

The liver-specific microRNA-122 (miR-122) recognizes two conserved sites at the 5′ end of the hepatitis C virus (HCV) genome and contributes to stability, translation, and replication of the viral RNA. We show that stimulation of the HCV internal ribosome entry site (IRES) by miR-122 is essential fo...

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Detalles Bibliográficos
Autores principales:	Schult, Philipp, Roth, Hanna, Adams, Rebecca L., Mas, Caroline, Imbert, Lionel, Orlik, Christian, Ruggieri, Alessia, Pyle, Anna M., Lohmann, Volker
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031695/ https://www.ncbi.nlm.nih.gov/pubmed/29973597 http://dx.doi.org/10.1038/s41467-018-05053-3

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