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Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases

BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocy...

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Autores principales: Gilani, Mitra Modares, Kazemi, Zohreh, Zamani, Narges, Shahrami, Hadis, Ghahghaei-Nezamabadi, Akram, Sheikham, Soureh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031787/
https://www.ncbi.nlm.nih.gov/pubmed/29693335
http://dx.doi.org/10.22034/APJCP.2018.19.4.897
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author Gilani, Mitra Modares
Kazemi, Zohreh
Zamani, Narges
Shahrami, Hadis
Ghahghaei-Nezamabadi, Akram
Sheikham, Soureh
author_facet Gilani, Mitra Modares
Kazemi, Zohreh
Zamani, Narges
Shahrami, Hadis
Ghahghaei-Nezamabadi, Akram
Sheikham, Soureh
author_sort Gilani, Mitra Modares
collection PubMed
description BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. METHODS: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. RESULTS: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23 x 10(9)/L ± 3.56 x 10(9)/L, 64.0 x 10(9)/L ± 11.3 x 10(9)/L and 261.6 x 10(9)/L ± 74.6 x 10(9). Statistically significant associations were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) and omentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement (p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377). CONCLUSION: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence rate in patients with endometrial cancer.
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spelling pubmed-60317872018-07-11 Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases Gilani, Mitra Modares Kazemi, Zohreh Zamani, Narges Shahrami, Hadis Ghahghaei-Nezamabadi, Akram Sheikham, Soureh Asian Pac J Cancer Prev Research Article BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. METHODS: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. RESULTS: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23 x 10(9)/L ± 3.56 x 10(9)/L, 64.0 x 10(9)/L ± 11.3 x 10(9)/L and 261.6 x 10(9)/L ± 74.6 x 10(9). Statistically significant associations were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) and omentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement (p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377). CONCLUSION: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence rate in patients with endometrial cancer. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6031787/ /pubmed/29693335 http://dx.doi.org/10.22034/APJCP.2018.19.4.897 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
spellingShingle Research Article
Gilani, Mitra Modares
Kazemi, Zohreh
Zamani, Narges
Shahrami, Hadis
Ghahghaei-Nezamabadi, Akram
Sheikham, Soureh
Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title_full Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title_fullStr Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title_full_unstemmed Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title_short Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
title_sort preoperative monocyte count as a mirror of tumor characteristics and likelihood of recurrence in endometrial carcinoma cases
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031787/
https://www.ncbi.nlm.nih.gov/pubmed/29693335
http://dx.doi.org/10.22034/APJCP.2018.19.4.897
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