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Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases
BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocy...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
West Asia Organization for Cancer Prevention
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031787/ https://www.ncbi.nlm.nih.gov/pubmed/29693335 http://dx.doi.org/10.22034/APJCP.2018.19.4.897 |
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author | Gilani, Mitra Modares Kazemi, Zohreh Zamani, Narges Shahrami, Hadis Ghahghaei-Nezamabadi, Akram Sheikham, Soureh |
author_facet | Gilani, Mitra Modares Kazemi, Zohreh Zamani, Narges Shahrami, Hadis Ghahghaei-Nezamabadi, Akram Sheikham, Soureh |
author_sort | Gilani, Mitra Modares |
collection | PubMed |
description | BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. METHODS: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. RESULTS: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23 x 10(9)/L ± 3.56 x 10(9)/L, 64.0 x 10(9)/L ± 11.3 x 10(9)/L and 261.6 x 10(9)/L ± 74.6 x 10(9). Statistically significant associations were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) and omentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement (p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377). CONCLUSION: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence rate in patients with endometrial cancer. |
format | Online Article Text |
id | pubmed-6031787 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | West Asia Organization for Cancer Prevention |
record_format | MEDLINE/PubMed |
spelling | pubmed-60317872018-07-11 Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases Gilani, Mitra Modares Kazemi, Zohreh Zamani, Narges Shahrami, Hadis Ghahghaei-Nezamabadi, Akram Sheikham, Soureh Asian Pac J Cancer Prev Research Article BACKGROUND: Recently preoperative hematologic parameters have attracted attention for their capacity to predict tumor characteristics and recurrence. Considering the established role of tumor-associated macrophages (TAM) in the tumor microenvironment, we evaluated the role of the preoperative monocyte count as a surrogate for TAM. METHODS: We retrospectively reviewed 166 patients with histopathologically proven endometrial cancers from January 2011 to March 2015 and assessed any association of preoperative monocyte count with tumor characteristics and recurrence. RESULTS: The majority of patients had tumors with the following characteristics: endometrioid histology (83.1%), low grade (grade I-II, 71.7%) and stage I disease (68.1%). The mean ± SD monocyte, neutrophil and platelet counts were 8.23 x 10(9)/L ± 3.56 x 10(9)/L, 64.0 x 10(9)/L ± 11.3 x 10(9)/L and 261.6 x 10(9)/L ± 74.6 x 10(9). Statistically significant associations were noted with between preoperative monocyte count and tumor stage (p value=0.044), recurrence (p value<0.001) and omentum involvement (p value< 0.001) but not with tumor grade (p value=0.897), depth of myometrium involvement (p value=0.479), lymphovascular space invasion (p value=0.269) and lymph node involvement (p value=0.377). CONCLUSION: An elevated preoperative monocyte count is related to more aggressive tumors and a higher recurrence rate in patients with endometrial cancer. West Asia Organization for Cancer Prevention 2018 /pmc/articles/PMC6031787/ /pubmed/29693335 http://dx.doi.org/10.22034/APJCP.2018.19.4.897 Text en Copyright: © Asian Pacific Journal of Cancer Prevention http://creativecommons.org/licenses/BY-SA/4.0 This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License |
spellingShingle | Research Article Gilani, Mitra Modares Kazemi, Zohreh Zamani, Narges Shahrami, Hadis Ghahghaei-Nezamabadi, Akram Sheikham, Soureh Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title | Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title_full | Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title_fullStr | Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title_full_unstemmed | Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title_short | Preoperative Monocyte Count as a Mirror of Tumor Characteristics and Likelihood of Recurrence in Endometrial Carcinoma Cases |
title_sort | preoperative monocyte count as a mirror of tumor characteristics and likelihood of recurrence in endometrial carcinoma cases |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031787/ https://www.ncbi.nlm.nih.gov/pubmed/29693335 http://dx.doi.org/10.22034/APJCP.2018.19.4.897 |
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