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Comparison of Salivary Cotinine Concentrations in Male Smokers and Smokeless Tobacco Users

OBJECTIVE: Smoking cigarettes and smokeless tobacco are one of the causes of oral cancer. This study compared the salivary level of cotinine in male smokeless tobacco users and smokers. METHODS: In this cross-sectional (descriptive-analytical) study, stimulated saliva samples from 30 male smokers an...

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Detalles Bibliográficos
Autores principales: Honarmand, Marieh, Nakhaee, Alireza, Moradi, Mohammad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: West Asia Organization for Cancer Prevention 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031843/
https://www.ncbi.nlm.nih.gov/pubmed/29802701
http://dx.doi.org/10.22034/APJCP.2018.19.5.1363
Descripción
Sumario:OBJECTIVE: Smoking cigarettes and smokeless tobacco are one of the causes of oral cancer. This study compared the salivary level of cotinine in male smokeless tobacco users and smokers. METHODS: In this cross-sectional (descriptive-analytical) study, stimulated saliva samples from 30 male smokers and 30 male smokeless tobacco consumers were collected and their cotinine contents were measured using the competitive ELISA method according the standard curve. The data was analyzed with independent t-test and linear regression using SPSS-19, and P<0.05 was considered significant. RESULT: Among the 60 subjects with the mean age of 21.27±2.6 years, the average level of cotinine in smokers (12.32±7.5 ng/ml) had no significant difference with that of smokeless tobacco consumers (11.23±4.4 ng/ml) (p=0.49). CONCLUSION: Salivary levels of cotinine were not significantly different in smokeless tobacco users and cigarette smokers. In addition, increases in the number of cigarettes smoked and in pack of smokeless tobacco used, were associated with increased salivary levels of cotinine. The increase was higher in smokeless tobacco consumers.