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Front Cover: Synthesis and Characterization of Novel Fluoro‐glycosylated Porphyrins that can be Utilized as Theranostic Agents (ChemistryOpen 7/2018)

The Front Cover shows a fluoro‐glycoporphyrin that selectively targets cancer cells. The selectivity towards cancer cells are afforded due to proper functionalization of the porphyrin scaffold with specific carbohydrates, and the cancer cells can be visualized because of the intrinsic fluorescence f...

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Detalles Bibliográficos
Autores principales: Arja, Katriann, Elgland, Mathias, Appelqvist, Hanna, Konradsson, Peter, Lindgren, Mikael, Nilsson, K. Peter R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031854/
http://dx.doi.org/10.1002/open.201800096
Descripción
Sumario:The Front Cover shows a fluoro‐glycoporphyrin that selectively targets cancer cells. The selectivity towards cancer cells are afforded due to proper functionalization of the porphyrin scaffold with specific carbohydrates, and the cancer cells can be visualized because of the intrinsic fluorescence from the porphyrin. The molecule also exhibits properties for photodynamic therapy and the incorporation of fluorine, in the form of 2‐fluoro‐2‐deoxy glucose, offers the possibility to apply these compounds as 18F positron emission tomography tracers. Thus, fluoro‐glycoporphyrins display multimodal properties and can be employed as theranostic agents targeting cancer cells. More information can be found in the Full Paper by K. P. R. Nilsson and co‐workers on page 495 in Issue 7, 2018 (DOI: https://doi.org/10.1002/open.201800020).[Image: see text]