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Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction
BACKGROUND: The objective of this study was to compare hemodynamic and recovery characteristics of total intravenous anesthesia using propofol target-controlled infusion (TCI) versus sevoflurane for extraction of four third molar teeth. METHODS: One hundred patients undergoing extraction of four thi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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The Korean Dental Society of Anesthsiology
2018
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031969/ https://www.ncbi.nlm.nih.gov/pubmed/29984321 http://dx.doi.org/10.17245/jdapm.2018.18.3.169 |
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author | Chung, Patrick K Dhanrajani, Parmanand |
author_facet | Chung, Patrick K Dhanrajani, Parmanand |
author_sort | Chung, Patrick K |
collection | PubMed |
description | BACKGROUND: The objective of this study was to compare hemodynamic and recovery characteristics of total intravenous anesthesia using propofol target-controlled infusion (TCI) versus sevoflurane for extraction of four third molar teeth. METHODS: One hundred patients undergoing extraction of four third molar teeth under general anesthesia were randomized to one of two groups. Group 1 received propofol TCI-oxygen for induction and propofol TCI-oxygen-air for maintenance. Group II received a propofol bolus of 2 mg/kg for induction and sevoflurane-oxygen-air for maintenance. Heart rate, mean arterial pressure (MAP), operating time, time to emergence, nausea and vomiting, and sedation and pain scores were measured in each group. RESULTS: Demographic data, including age, gender, weight, and height, were not significantly different between the two groups. The MAP was significantly higher after intubation (P = 0.007) and injection of anesthesia (P = 0.004) in the propofol group than in the sevoflurane group, with significant reflex bradycardia (P = 0.028). The mean time to emergence from anesthesia using propofol was 25 s shorter than that of sevoflurane (P = 0.02). Postoperatively, the propofol group was less sedated than the sevoflurane group at 30 min (0.02 versus 0.12), but this difference was not significant (P = 0.065). CONCLUSION: Both propofol TCI and sevoflurane are good alternatives for induction and maintenance of anesthesia for short day-case surgery. However, propofol TCI does not blunt the hemodynamic response to sudden, severe stimuli as strongly as sevoflurane, and this limitation may be a cause for concern in patients with cardiac comorbidities. |
format | Online Article Text |
id | pubmed-6031969 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | The Korean Dental Society of Anesthsiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-60319692018-07-07 Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction Chung, Patrick K Dhanrajani, Parmanand J Dent Anesth Pain Med Original Article BACKGROUND: The objective of this study was to compare hemodynamic and recovery characteristics of total intravenous anesthesia using propofol target-controlled infusion (TCI) versus sevoflurane for extraction of four third molar teeth. METHODS: One hundred patients undergoing extraction of four third molar teeth under general anesthesia were randomized to one of two groups. Group 1 received propofol TCI-oxygen for induction and propofol TCI-oxygen-air for maintenance. Group II received a propofol bolus of 2 mg/kg for induction and sevoflurane-oxygen-air for maintenance. Heart rate, mean arterial pressure (MAP), operating time, time to emergence, nausea and vomiting, and sedation and pain scores were measured in each group. RESULTS: Demographic data, including age, gender, weight, and height, were not significantly different between the two groups. The MAP was significantly higher after intubation (P = 0.007) and injection of anesthesia (P = 0.004) in the propofol group than in the sevoflurane group, with significant reflex bradycardia (P = 0.028). The mean time to emergence from anesthesia using propofol was 25 s shorter than that of sevoflurane (P = 0.02). Postoperatively, the propofol group was less sedated than the sevoflurane group at 30 min (0.02 versus 0.12), but this difference was not significant (P = 0.065). CONCLUSION: Both propofol TCI and sevoflurane are good alternatives for induction and maintenance of anesthesia for short day-case surgery. However, propofol TCI does not blunt the hemodynamic response to sudden, severe stimuli as strongly as sevoflurane, and this limitation may be a cause for concern in patients with cardiac comorbidities. The Korean Dental Society of Anesthsiology 2018-06 2018-06-29 /pmc/articles/PMC6031969/ /pubmed/29984321 http://dx.doi.org/10.17245/jdapm.2018.18.3.169 Text en Copyright © 2018 Journal of Dental Anesthesia and Pain Medicine http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Chung, Patrick K Dhanrajani, Parmanand Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title | Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title_full | Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title_fullStr | Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title_full_unstemmed | Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title_short | Comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
title_sort | comparative randomized study of propofol target-controlled infusion versus sevoflurane anesthesia for third molar extraction |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6031969/ https://www.ncbi.nlm.nih.gov/pubmed/29984321 http://dx.doi.org/10.17245/jdapm.2018.18.3.169 |
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