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Design, Synthesis, Cytotoxic Evaluation and Molecular Docking of New Fluoroquinazolinones as Potent Anticancer Agents with Dual EGFR Kinase and Tubulin Polymerization Inhibitory Effects
A series of new fluoroquinazolinone 6–8 and 10a–g derivatives was designed, prepared and screened for their in vitro cytotoxic activity against human cancer cell lines MCF-7 and MDA-MBA-231. Compounds 6 (IC(50) = 0.35 ± 0.01 µM), 10f (IC(50) = 0.71 ± 0.01 µM), 10d (IC(50) = 0.89 ± 0.02 µM) and 10a (...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2018
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032053/ https://www.ncbi.nlm.nih.gov/pubmed/29891789 http://dx.doi.org/10.3390/ijms19061731 |