Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer

Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies in chronic inflammatory diseases. MicroRNAs (miRNAs) have been demonstrated to play important roles in macrophage functions by regulating macrophage polarization, lipid metabolism and so on....

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Detalles Bibliográficos
Autores principales: Wei, Yuanyuan, Zhu, Mengyu, Schober, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032097/
https://www.ncbi.nlm.nih.gov/pubmed/29899293
http://dx.doi.org/10.3390/ijms19061756
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author Wei, Yuanyuan
Zhu, Mengyu
Schober, Andreas
author_facet Wei, Yuanyuan
Zhu, Mengyu
Schober, Andreas
author_sort Wei, Yuanyuan
collection PubMed
description Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies in chronic inflammatory diseases. MicroRNAs (miRNAs) have been demonstrated to play important roles in macrophage functions by regulating macrophage polarization, lipid metabolism and so on. Thus, miRNAs represent promising diagnostic and therapeutic targets in immune disorders. In this review, we will summarize the role of miRNAs in atherosclerosis, metabolic syndrome, and cancer by modulating macrophage phenotypes, which has been supported by in vivo evidence.
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spelling pubmed-60320972018-07-13 Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer Wei, Yuanyuan Zhu, Mengyu Schober, Andreas Int J Mol Sci Review Macrophages play a crucial role in the innate immune system and contribute to a broad spectrum of pathologies in chronic inflammatory diseases. MicroRNAs (miRNAs) have been demonstrated to play important roles in macrophage functions by regulating macrophage polarization, lipid metabolism and so on. Thus, miRNAs represent promising diagnostic and therapeutic targets in immune disorders. In this review, we will summarize the role of miRNAs in atherosclerosis, metabolic syndrome, and cancer by modulating macrophage phenotypes, which has been supported by in vivo evidence. MDPI 2018-06-13 /pmc/articles/PMC6032097/ /pubmed/29899293 http://dx.doi.org/10.3390/ijms19061756 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wei, Yuanyuan
Zhu, Mengyu
Schober, Andreas
Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title_full Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title_fullStr Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title_full_unstemmed Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title_short Macrophage MicroRNAs as Therapeutic Targets for Atherosclerosis, Metabolic Syndrome, and Cancer
title_sort macrophage micrornas as therapeutic targets for atherosclerosis, metabolic syndrome, and cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032097/
https://www.ncbi.nlm.nih.gov/pubmed/29899293
http://dx.doi.org/10.3390/ijms19061756
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AT zhumengyu macrophagemicrornasastherapeutictargetsforatherosclerosismetabolicsyndromeandcancer
AT schoberandreas macrophagemicrornasastherapeutictargetsforatherosclerosismetabolicsyndromeandcancer

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