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Signaling Crosstalk of TGF-β/ALK5 and PAR2/PAR1: A Complex Regulatory Network Controlling Fibrosis and Cancer

Both signaling by transforming growth factor-β (TGF-β) and agonists of the G Protein-coupled receptors proteinase-activated receptor-1 (PAR1) and -2 (PAR2) have been linked to tissue fibrosis and cancer. Intriguingly, TGF-β and PAR signaling either converge on the regulation of certain matrix genes...

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Detalles Bibliográficos
Autores principales:	Ungefroren, Hendrik, Gieseler, Frank, Kaufmann, Roland, Settmacher, Utz, Lehnert, Hendrik, Rauch, Bernhard H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032192/ https://www.ncbi.nlm.nih.gov/pubmed/29795022 http://dx.doi.org/10.3390/ijms19061568

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