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Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex

Human leukocyte antigen (HLA)-DRB1*01:01 has been shown to be involved in nevirapine-induced hepatic hypersensitivity reactions. In the present study, in silico docking simulations and molecular dynamics simulations were performed to predict the interaction mode of nevirapine with the peptide bindin...

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Detalles Bibliográficos
Autores principales:	Hirasawa, Makoto, Hagihara, Katsunobu, Abe, Koji, Ando, Osamu, Hirayama, Noriaki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2018
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032195/ https://www.ncbi.nlm.nih.gov/pubmed/29867033 http://dx.doi.org/10.3390/ijms19061660

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