Cargando…
Connexins and Pannexins in Vascular Function and Disease
Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial ro...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2018
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032213/ https://www.ncbi.nlm.nih.gov/pubmed/29874791 http://dx.doi.org/10.3390/ijms19061663 |
_version_ | 1783337462062383104 |
---|---|
author | Molica, Filippo Figueroa, Xavier F. Kwak, Brenda R. Isakson, Brant E. Gibbins, Jonathan M. |
author_facet | Molica, Filippo Figueroa, Xavier F. Kwak, Brenda R. Isakson, Brant E. Gibbins, Jonathan M. |
author_sort | Molica, Filippo |
collection | PubMed |
description | Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes. |
format | Online Article Text |
id | pubmed-6032213 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-60322132018-07-13 Connexins and Pannexins in Vascular Function and Disease Molica, Filippo Figueroa, Xavier F. Kwak, Brenda R. Isakson, Brant E. Gibbins, Jonathan M. Int J Mol Sci Review Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes. MDPI 2018-06-05 /pmc/articles/PMC6032213/ /pubmed/29874791 http://dx.doi.org/10.3390/ijms19061663 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Molica, Filippo Figueroa, Xavier F. Kwak, Brenda R. Isakson, Brant E. Gibbins, Jonathan M. Connexins and Pannexins in Vascular Function and Disease |
title | Connexins and Pannexins in Vascular Function and Disease |
title_full | Connexins and Pannexins in Vascular Function and Disease |
title_fullStr | Connexins and Pannexins in Vascular Function and Disease |
title_full_unstemmed | Connexins and Pannexins in Vascular Function and Disease |
title_short | Connexins and Pannexins in Vascular Function and Disease |
title_sort | connexins and pannexins in vascular function and disease |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032213/ https://www.ncbi.nlm.nih.gov/pubmed/29874791 http://dx.doi.org/10.3390/ijms19061663 |
work_keys_str_mv | AT molicafilippo connexinsandpannexinsinvascularfunctionanddisease AT figueroaxavierf connexinsandpannexinsinvascularfunctionanddisease AT kwakbrendar connexinsandpannexinsinvascularfunctionanddisease AT isaksonbrante connexinsandpannexinsinvascularfunctionanddisease AT gibbinsjonathanm connexinsandpannexinsinvascularfunctionanddisease |