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Connexins and Pannexins in Vascular Function and Disease

Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial ro...

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Autores principales: Molica, Filippo, Figueroa, Xavier F., Kwak, Brenda R., Isakson, Brant E., Gibbins, Jonathan M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032213/
https://www.ncbi.nlm.nih.gov/pubmed/29874791
http://dx.doi.org/10.3390/ijms19061663
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author Molica, Filippo
Figueroa, Xavier F.
Kwak, Brenda R.
Isakson, Brant E.
Gibbins, Jonathan M.
author_facet Molica, Filippo
Figueroa, Xavier F.
Kwak, Brenda R.
Isakson, Brant E.
Gibbins, Jonathan M.
author_sort Molica, Filippo
collection PubMed
description Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes.
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spelling pubmed-60322132018-07-13 Connexins and Pannexins in Vascular Function and Disease Molica, Filippo Figueroa, Xavier F. Kwak, Brenda R. Isakson, Brant E. Gibbins, Jonathan M. Int J Mol Sci Review Connexins (Cxs) and pannexins (Panxs) are ubiquitous membrane channel forming proteins that are critically involved in many aspects of vascular physiology and pathology. The permeation of ions and small metabolites through Panx channels, Cx hemichannels and gap junction channels confers a crucial role to these proteins in intercellular communication and in maintaining tissue homeostasis. This review provides an overview of current knowledge with respect to the pathophysiological role of these channels in large arteries, the microcirculation, veins, the lymphatic system and platelet function. The essential nature of these membrane proteins in vascular homeostasis is further emphasized by the pathologies that are linked to mutations and polymorphisms in Cx and Panx genes. MDPI 2018-06-05 /pmc/articles/PMC6032213/ /pubmed/29874791 http://dx.doi.org/10.3390/ijms19061663 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Molica, Filippo
Figueroa, Xavier F.
Kwak, Brenda R.
Isakson, Brant E.
Gibbins, Jonathan M.
Connexins and Pannexins in Vascular Function and Disease
title Connexins and Pannexins in Vascular Function and Disease
title_full Connexins and Pannexins in Vascular Function and Disease
title_fullStr Connexins and Pannexins in Vascular Function and Disease
title_full_unstemmed Connexins and Pannexins in Vascular Function and Disease
title_short Connexins and Pannexins in Vascular Function and Disease
title_sort connexins and pannexins in vascular function and disease
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032213/
https://www.ncbi.nlm.nih.gov/pubmed/29874791
http://dx.doi.org/10.3390/ijms19061663
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