Potential Clinical Application of Genomics in Multiple Myeloma

Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible ther...

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Autores principales: Soekojo, Cinnie Yentia, de Mel, Sanjay, Ooi, Melissa, Yan, Benedict, Chng, Wee Joo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032230/
https://www.ncbi.nlm.nih.gov/pubmed/29890777
http://dx.doi.org/10.3390/ijms19061721
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author Soekojo, Cinnie Yentia
de Mel, Sanjay
Ooi, Melissa
Yan, Benedict
Chng, Wee Joo
author_facet Soekojo, Cinnie Yentia
de Mel, Sanjay
Ooi, Melissa
Yan, Benedict
Chng, Wee Joo
author_sort Soekojo, Cinnie Yentia
collection PubMed
description Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma.
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spelling pubmed-60322302018-07-13 Potential Clinical Application of Genomics in Multiple Myeloma Soekojo, Cinnie Yentia de Mel, Sanjay Ooi, Melissa Yan, Benedict Chng, Wee Joo Int J Mol Sci Review Multiple myeloma is a heterogeneous disease with different characteristics, and genetic aberrations play important roles in this heterogeneity. Studies have shown that these genetic aberrations are crucial in prognostication and response assessment; recent efforts have focused on their possible therapeutic implications. Despite many emerging studies being published, the best way to incorporate these results into clinical practice remains unclear. In this review paper we describe the different genomic techniques available, including the latest advancements, and discuss the potential clinical application of genomics in multiple myeloma. MDPI 2018-06-10 /pmc/articles/PMC6032230/ /pubmed/29890777 http://dx.doi.org/10.3390/ijms19061721 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Soekojo, Cinnie Yentia
de Mel, Sanjay
Ooi, Melissa
Yan, Benedict
Chng, Wee Joo
Potential Clinical Application of Genomics in Multiple Myeloma
title Potential Clinical Application of Genomics in Multiple Myeloma
title_full Potential Clinical Application of Genomics in Multiple Myeloma
title_fullStr Potential Clinical Application of Genomics in Multiple Myeloma
title_full_unstemmed Potential Clinical Application of Genomics in Multiple Myeloma
title_short Potential Clinical Application of Genomics in Multiple Myeloma
title_sort potential clinical application of genomics in multiple myeloma
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032230/
https://www.ncbi.nlm.nih.gov/pubmed/29890777
http://dx.doi.org/10.3390/ijms19061721
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