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The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential

Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and s...

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Autores principales: Zhai, Qingpan, Han, Fengxuan, He, Zhiwei, Shi, Chen, Zhou, Pinghui, Zhu, Caihong, Guo, Qianping, Zhu, Xuesong, Yang, Huilin, Li, Bin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032233/
https://www.ncbi.nlm.nih.gov/pubmed/29895809
http://dx.doi.org/10.3390/ijms19061746
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author Zhai, Qingpan
Han, Fengxuan
He, Zhiwei
Shi, Chen
Zhou, Pinghui
Zhu, Caihong
Guo, Qianping
Zhu, Xuesong
Yang, Huilin
Li, Bin
author_facet Zhai, Qingpan
Han, Fengxuan
He, Zhiwei
Shi, Chen
Zhou, Pinghui
Zhu, Caihong
Guo, Qianping
Zhu, Xuesong
Yang, Huilin
Li, Bin
author_sort Zhai, Qingpan
collection PubMed
description Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and stress shielding. In this study, we aimed to develop a new type of partially biodegradable composite bone cement by incorporating magnesium (Mg) microspheres, known as “Mg sacrifices” (MgSs), in the PMMA matrix. Being sensitive to the physiological environment, the MgSs in PMMA could gradually degrade to produce bioactive Mg ions and, meanwhile, result in an interconnected macroporous structure within the cement matrix. The mechanical properties, solidification, and biocompatibility, both in vitro and in vivo, of PMMA–Mg bone cement were characterized. Interestingly, the incorporation of Mg microspheres did not markedly affect the mechanical strength of bone cement. However, the maximum temperature upon setting of bone cement decreased. This partially biodegradable composite bone cement showed good biocompatibility in vitro. In the in vivo study, considerable bony ingrowth occurred in the pores upon MgS degradation. Together, the findings from this study indicate that such partially biodegradable PMMA–Mg composite may be ideal bone cement for minimally invasive orthopedic surgeries such as vertebroplasty and kyphoplasty.
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spelling pubmed-60322332018-07-13 The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential Zhai, Qingpan Han, Fengxuan He, Zhiwei Shi, Chen Zhou, Pinghui Zhu, Caihong Guo, Qianping Zhu, Xuesong Yang, Huilin Li, Bin Int J Mol Sci Article Poly (methyl methacrylate) (PMMA)-based bone cements are the most commonly used injectable orthopedic materials due to their excellent injectability and mechanical properties. However, their poor biocompatibility and excessive stiffness may cause complications such as aseptic implant loosening and stress shielding. In this study, we aimed to develop a new type of partially biodegradable composite bone cement by incorporating magnesium (Mg) microspheres, known as “Mg sacrifices” (MgSs), in the PMMA matrix. Being sensitive to the physiological environment, the MgSs in PMMA could gradually degrade to produce bioactive Mg ions and, meanwhile, result in an interconnected macroporous structure within the cement matrix. The mechanical properties, solidification, and biocompatibility, both in vitro and in vivo, of PMMA–Mg bone cement were characterized. Interestingly, the incorporation of Mg microspheres did not markedly affect the mechanical strength of bone cement. However, the maximum temperature upon setting of bone cement decreased. This partially biodegradable composite bone cement showed good biocompatibility in vitro. In the in vivo study, considerable bony ingrowth occurred in the pores upon MgS degradation. Together, the findings from this study indicate that such partially biodegradable PMMA–Mg composite may be ideal bone cement for minimally invasive orthopedic surgeries such as vertebroplasty and kyphoplasty. MDPI 2018-06-12 /pmc/articles/PMC6032233/ /pubmed/29895809 http://dx.doi.org/10.3390/ijms19061746 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zhai, Qingpan
Han, Fengxuan
He, Zhiwei
Shi, Chen
Zhou, Pinghui
Zhu, Caihong
Guo, Qianping
Zhu, Xuesong
Yang, Huilin
Li, Bin
The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title_full The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title_fullStr The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title_full_unstemmed The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title_short The “Magnesium Sacrifice” Strategy Enables PMMA Bone Cement Partial Biodegradability and Osseointegration Potential
title_sort “magnesium sacrifice” strategy enables pmma bone cement partial biodegradability and osseointegration potential
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032233/
https://www.ncbi.nlm.nih.gov/pubmed/29895809
http://dx.doi.org/10.3390/ijms19061746
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