Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer

By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP....

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Detalles Bibliográficos
Autores principales: Liu, Hengyuan, Cao, Tianyang, Xu, Yun, Dong, Yuanchen, Liu, Dongsheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2018
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032235/
https://www.ncbi.nlm.nih.gov/pubmed/29857520
http://dx.doi.org/10.3390/ijms19061633
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author Liu, Hengyuan
Cao, Tianyang
Xu, Yun
Dong, Yuanchen
Liu, Dongsheng
author_facet Liu, Hengyuan
Cao, Tianyang
Xu, Yun
Dong, Yuanchen
Liu, Dongsheng
author_sort Liu, Hengyuan
collection PubMed
description By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa.
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spelling pubmed-60322352018-07-13 Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer Liu, Hengyuan Cao, Tianyang Xu, Yun Dong, Yuanchen Liu, Dongsheng Int J Mol Sci Communication By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with the addition of the complementary sequence to the ATP aptamer, the mechanical strength could be increased to 570 Pa. MDPI 2018-05-31 /pmc/articles/PMC6032235/ /pubmed/29857520 http://dx.doi.org/10.3390/ijms19061633 Text en © 2018 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Liu, Hengyuan
Cao, Tianyang
Xu, Yun
Dong, Yuanchen
Liu, Dongsheng
Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_full Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_fullStr Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_full_unstemmed Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_short Tuning the Mechanical Properties of a DNA Hydrogel in Three Phases Based on ATP Aptamer
title_sort tuning the mechanical properties of a dna hydrogel in three phases based on atp aptamer
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6032235/
https://www.ncbi.nlm.nih.gov/pubmed/29857520
http://dx.doi.org/10.3390/ijms19061633
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AT caotianyang tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT xuyun tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT dongyuanchen tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer
AT liudongsheng tuningthemechanicalpropertiesofadnahydrogelinthreephasesbasedonatpaptamer

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